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Which of the following side effects is most strongly associated with the use of NSAIDs?
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Which of the following is true regarding the COX-2 enzyme?
It regulates normal cellular processes and is the primarily constitutive form of the COX enzymes
It decreases prostaglandin production in bone in the presence of certain osteotropic factors
It is thought to be necessary for normal endochondral ossification during fracture healing
Inhibition of COX-2 has been definitively shown to impede bone healing in human clinical studies
Pharmocologic COX-2 inhibition commonly leads to more gastric irritation than COX-1 inhibition
Which of the following is NOT a described complication of corticosteroid injections?
Local flare in surrounding tissues
Apoptosis of myocytes
Skin pigmentation changes
All the following medications binds reversibly to the enzyme COX-1 EXCEPT
Arachidonic acid is directly metabolized by which of the following substances?
A 45-year-old man is placed on indomethacin for heterotopic ossification prophylaxis following surgery for an acetabular fracture. What is the most likely side effect of this medication?
Deep vein thrombosis