Review Question - QID 3164

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Anti-inflammatory Medications COX Inhibitors NSAIDS inhibit both COX-1 and COX-2 QID: 3164 (OBQ10.76)

QID 3164 (Type "3164" in App Search)

All the following medications binds reversibly to the enzyme COX-1 EXCEPT

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Meloxicam

13%

442/3465

Diclofenac

88/3465

Indomethacin

116/3465

Naproxen sodium

71/3465

Aspirin

79%

2737/3465

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Aspirin binds irreversibly to the cyclooxygenase enzyme. Aspirin acetylates platelet cyclooxygenase and permanently inhibits thromboxane (TX) A2 production leading to its antiplatelet effects. The other NSAID's listed above bind reversibly with COX-1.

Patrono et al discuss the pharmokinetics and platelet effect of both low dose and regular dose aspirin. Nonsteroidal anti-inflammatory drugs compete dose-dependently with arachidonate for binding to platelet cyclooxygenase.