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Where in the coagulation cascade shown in Figure A does enoxaparin primarily exert its effects?
Select Answer to see Preferred Response
Which of the following agents results in blood anticoagulation by exerting inhibitory effects on the factor circled in the color red in Figure A?
Tranexamic acid (TXA)
Which of the following medications used for thromboprophylaxis following orthoapedic surgery is a direct inhibitor of factor Xa?
Which of the following medications works through the competitive inhibition of plasminogen activation?
Which of the following pharmacologic agents is associated with the highest risk of bleeding and thrombocytopenia?
All of the following are AAOS recommendations regarding prevention of venous thromboembolic disease (VTED) in patients undergoing elective hip and knee arthroplasty EXCEPT?
Patients should discontinue antiplatelet agents before undergoing elective hip or knee arthroplasty
Aspirin is not approved as a preventative medication for VTED in low risk patients
Neuraxial (epidural, spinal, intrathecal) anesthesia is recommended when possible
Routine post-operative duplex ultrasonography screening is not recommended
Mechanical prophylaxis mechanisms are recommended in patients with a known bleeding disorder
Which of the following supplements affects blood clotting through its effect on platelets?
St. John's Wort
Which drug works by preventing gamma carboxylation in factor X, factor IX, and prothrombin?
Low-molecular-weight heparin has been shown to have an increased rate of which of the following when compared to aspirin, clopidogrel, and compression devices?
Fatal pulmonary embolism
Inferior vena cava filter placement
What is the mechanism of action of warfarin?
Binds to platelets and inhibits their aggregation
Inhibits vitamin K-dependent clotting factors
Blocks COX-2 function
Unselective COX inhibiter
Decreases Anti-thrombin III activity
Figure 33 shows the venogram of a patient who has a long history of alcohol abuse. Warfarin should be used cautiously because of the interaction with which of the following factors?
Protamine functions to reverse the pharmacologic effects of which of the following anti-coagulants?
Clopidogrel (e.g. plavix)
Low molecular weight heparin
Which of the following medications exerts its influence on the clotting cascade by inhibiting the carboxylation of normal clotting factors?