In this study, we evaluated the hemostatic effects of tranexamic acid (TNA), an antifibrinolytic drug, by examining the timing of its administration during total hip arthroplasty. One hundred seven patients being treated for osteoarthritis of the hip joint were randomly divided into 5 groups based on the timing of TNA administration. The intraoperative blood loss, postoperative blood loss, and hemoglobin of these patients who received TNA at different times during the procedure were monitored. We found that the intraoperative blood loss in the preoperative TNA administration groups was significantly lower than both control and postoperative TNA administration groups. Furthermore, 1 g TNA 10 minutes before surgery and 6 hours after the first administration was most effective for the reduction of blood loss during total hip arthroplasty.





Polls results
1

On a scale of 1 to 10, rate how much this article will change your clinical practice?

NO change
BIG change
77% Article relates to my practice (17/22)
13% Article does not relate to my practice (3/22)
9% Undecided (2/22)
2

Will this article lead to more cost-effective healthcare?

90% Yes (20/22)
9% No (2/22)
0% Undecided (0/22)
3

Was this article biased? (commercial or personal)

4% Yes (1/22)
90% No (20/22)
4% Undecided (1/22)
4

What level of evidence do you think this article is?

22% Level 1 (5/22)
22% Level 2 (5/22)
27% Level 3 (6/22)
22% Level 4 (5/22)
4% Level 5 (1/22)