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Which of the following bleeding disorders is caused by an X-linked recessive mutation?
Factor VIII deficiency
Factor IX deficiency
Factor XI deficiency
Von Willibrand factor deficiency
Both 1 & 2
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A 48-year-old man who is scheduled to undergo total knee replacement has an X-linked clotting disorder that leads to abnormal bleeding and recurrent, spontaneous hemarthrosis. Before undergoing surgery, he should have replacement therapy of
protein C and S.
von Willebrand factor.