summary Reiter's Syndrome is a seronegative spondyloarthropathy, often caused by an underlying infection, that typically presents with urethritis, ocular conjunctivitis, uveitis, and/or arthritis. Diagnosis is made clinically based on history, symptoms, and ophthalmologic exam. Treatment is usually antibiotics, symptomatic treatment, and observation. Epidemiology Incidence rare Demographics occurs most commonly in young man (<40 years of age) rarely occurs in children, but sometimes appears in adolescents Anatomic location arthritis login to view 2 more bullets Etiology Diagnostic criteria urethritis conjunctivitis or uveitis arthritis Pathophysiology associated infections login to view 6 more bullets Genetics may be genetic component making certain individuals more susceptible Presentation Symptoms urinary discomfort or pain login to view 1 more bullet inflammation or dryness of the eye joint pain login to view 1 more bullet other non-specific pain symptoms including login to view 2 more bullets Physical exam nongonococcal urethritis conjunctivitis or uveitis arthritis skin lesions on palms/soles login to view 2 more bullets low-grade fever Imaging Radiographs may identify arthritis of the joints Studies Diagnosis is based primarily on symptoms and presentation Labs HLA-B27 positive in 75% of cases CRP elevated ESR elevated Urinalysis may identify signs of active infection Treatment Nonoperative antibiotics, symptomatic treatment, observation login to view 6 more bullets systemic steroids login to view 2 more bullets Complications Aortic insufficiency Arrhythmia Prognosis Most cases resolve within weeks, but can last up to months Recurrence occurs in up to half of cases over period of several years