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A 29-year-old female complains of increasing severity back pain for the past 4 months. Radiograph, CT scan, T1 and T2 MRI, and biopsy specimen are shown in Figures A through E. What is the most likely diagnosis?
Giant cell tumor
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Which of the following radiographs demonstrates a tumor that would be best treated by curettage with a power burr and packing with cement?
A 33-year-old female reports lateral knee pain and slight fullness. She underwent a bone scan which showed increased activity isolated to the proximal fibula. Radiographs and histology are shown in Figures A and B. What is the most likely diagnosis?
Giant cell tumors of bone can be locally aggressive and result in significant bone destruction. Which of the following is responsible for this type of bone destruction?
Multinuclear giant cells
Osteocytic stromal cells
Tumor cell activation of osteoclasts
Tumor cell inactivation of osteoblasts
Osteoprotegrin activation of osteoclasts
A 40-year-old female presents with dull pain in her knee that has been increasing in severity over the past 6 months. Figures A through D show representative radiographs, MRI, and biopsy section. What is the most appropriate treatment?
Bone marrow biopsy
Intra-lesional curettage with local adjuvant therapy
Neoadjuvant chemotherapy, surgical excision, and adjuvant chemotherapy
Neoadjuvant radiotherapy and surgical excision
A 41-year-old male presents with 6 months of wrist pain and swelling. He is otherwise healthy and denies trauma. Clincal photograph, radiographs, MRI, and histology are shown in Figures A through E. What is the most likely diagnosis?
Aneurysmal bone cyst
A 21-year-old man presents with a lytic lesion in his distal femur. A chest radiograph reveals a lung nodule. Which of the following tumors most likely to metastasize to lung ?
Giant cell tumor
All of the following locations are common sites for giant cell tumor of bone to occur EXCEPT?
Posterior elements of the spine
Giant cell tumors of bone can occur in many different areas throughout the body. All of the following are common locations for giant cell tumors of bone EXCEPT?
Phalanges of the hand
Figures A-E show skeletal distribution of common bone tumors. Which figure shows the most common sites of giant cell tumor distribution in bone?