Introduction Overview A Giant Cell Tumor (GCT) is a benign aggressive tumor typically found in the metaphysis of long bones, often around the knee, in young adults treatment is generally curretage, adjuvant treatment, and reconstruction as necessary depending on location of lesion Epidemiology incidence 1.7 per million people demographics more common in females (unlike most bone tumors which show male predominance) ages 30-50 years location distal femur > proximal tibia > distal radius > sacral ala 50% occur around knee (distal femur or proximal tibia) 10% in sacrum and vertebrae (sacral ala is most common site in axial skeleton) in the spine it usually occurs in the vertebral body phalanges of the hand is also a very common location may arise in the apophysis (like chondroblastoma) Genetics mutations metastatic lesions often noted to have altertions in c-myc oncogene or p53 Associated conditions malignancy primary malignant giant cell tumor metastatic to lung in 2-4% of cases wrist and hand lesions have greater chance of metastasis secondary malignant giant cell tumor occurs following radiation or multiple resections of giant cell tumor Prognosis metastatic GCT has a 5 year 76% disease-free survival rate and a 17% mortality rate. Presentation Symptoms pain insidious onset of pain of the involved extremity with activity, at night, or at rest pain referable to involved joint night pain (result of tumor expansion) difficulty ambulating swelling Physical exam inspection & palpation palpable mass tenderness over mass soft tissue swelling if peri-articular lesion, joint effusion can be present motion decreased range of motion around affected joint gait antalgic Imaging Radiographs recommended views extremity involved chest x-ray to evaluate for lung metastasis findings eccentric lytic epiphyseal/metaphyseal lesion that often extends into the distal epiphysis and borders subchondral bone "neo-cortex" is characteristic of benign aggressive lesions, and not unique to GCT CT recommend views chest CT to evaluate for pulmonary metatases occurs in 1-6% findings lung metastases are usually benign (histologically similar to primary bone tumor) MRI indications to evalute for extent of lesion findings tumor blushing cystic degeneration shows clear demarcation on T1 image between fatty marrow and tumor dark on T1, bright on T2 and avid on gadolinium enhanced Bone scan findings is very hot Studies Histology characteristic cells type I cell mononuclear stromal cell that resembles interstitial fibroblasts this is the neoplastic/tumor cell has features of mesenchymal stem cells type II cell from monocyte/macrophage family recruited from peripheral blood precursors of giant cells type III cell numerous giant cells are the hallmark of this lesion nuclei nuclei of giant cell appears same as stromal cells multiple nuclei (up to 50 per cell) similar characteristics as osteoclasts and resorb bone have same enzymes (tartrate resistant acid phosphatase, carbonic anhydrase II, cathepsin K, vacuolar ATPase) secondary ABC degeneration is not uncommon molecular biology type II and III cells have IGF-I and IGF-II activity 80% of patients with GCT have telomeric associations (tas) abnormality in half the cells RANK pathway is important denosumab acts on this pathway Differential Brown tumor of hyperparathyroidism can look like GCT on radiographs except it occurs as multiple lesions and associated with serum calcium level abnormalities Chondroblastoma epiphyseal location may also demonstrate ABC formation has extensive surrounding soft tissue and marrow edema may have sclerotic margin and central calcification of chondroid matrix "ring and arcs" pattern Osteosarcoma telangiectatic OS giant cell-rich OS fibroblastic OS Chordoma (mimics GCT sacrum) occurs in midline Epiphyseal lesion Treatment is USUALLY currettage and bone grafting(1) Giant Cell Tumor • • Chondroblastoma • • Aneurysmal Bone cyst • Osteoblastoma • Chondromyoid fibroma (CMF) • ASSUMPTIONS: (1) assuming no impending fracture Treatment Nonoperative radiation therapy indications only indicated for inoperable or multiply recurrent lesions sacral lesions and large vertebral body lesions that are not ammendable to surgery outcomes leads to 15% malignant transformation medical management (denosumab, bisphosphanates) indications stabilize lesions augment or replace surgical management depending on the specific clinical scenario outcomes excellent response has been seen with denosumab (85-90% destruction of giant cells) post-surgical treatment with diphosphonate has shown to lower recurrence rates by 25-30% Operative extensive curettage, adjuvant treatment and reconstruction indications lesions amenable to currettage majority of lower extremity lesions hand lesion treatment is most controversial outcomes 20-40% recurrence with curettage and bone grafting alone versus 3-10% with addition of adjuvant treatment (phenol, hydrogen peroxide, cryo, argon beam, high-speed burr) complete resection and reconstruction indications when currettage not possible due to structural compromise with extensive involvement of vertebral body complete en bloc spondylectomy may be required outcomes the 10 year disease-free survival rates after total en bloc spondylectomy for GCT is reported to be 100% in some studies. amputation indications hand lesions with cortical breakthrough who are not amendable to intercalary resection outcomes has the lowest incidence of recurrence Techniques Radiation therapy technique external beam radiation Medical management technique bisphosphonates osteclast inhibitors which may decrease the size of the defect in giant cell tumors and help prevent post-surgical recurrence denosumab monoclonal antibody against RANK-ligand recent clinical trials suggest denosumab can decrease the size of the bone defect in giant cell tumor 85-90% tumor necrosis shows dramatic sclerosis and reconstitution of cortical bone after treatment complications bisphosphonates esophagitis, gastritis, long term use can lead to atypical subtrochanteric femur fractures denosumb may cause nasopharyngitis, arthralgias contraindications severe hypocalcemia Extensive curretage, adjuvant treatment and reconstruction extensive curretage technique challenge of treatment is to remove lesion while preserving joint and providing support to subchondral joint extensive exterioration (removal of a large cortical window over the lesion) is required hand curretage is the most controversal if no cortical breakthrough treat with curettage and cementing if significant cortical breakthrough consider intercalary resection (with free fibular graft) vs. amputation adjuvant treatment technique phenol, liquid nitrogen, hydrogen peroxide, argon beam, high-speed burr can be effectively used in isolation or combination to reduce recurrence rates local recurrence rates with supplementation of ethanol and phenol are identical high-speed burr without any other adjuvant has recurrence rate of 12% complications liquid nitrogen (aka cryotherapy) has been associated with an increased incidence of pathologic fracture and vascular injury reconstruction technique fill lesion with bone cement or bone graft and supplement with internal fixation structural allograft, endoprosthetic implants or combinations of two for large lesions or in setting of extensive bone destruction Complete resection and reconstruction approach based on location in the spine (lumbar, thoracic, cervical) anterior, posterior or combined anterior approach in the lumbar spine may be direct lateral, oblique lateral or transperitoneal depending on specific level technique can be single or 2-staged procedure 1st stage would involve total vertebral spondylectomy, adjuvant treatment with placement of a reconstruction expandable cage and anterior plating alternatively can use bone cement in lieu of a structural cage. may require nerve root resection based on spinal level and involvement of nerve roots within tumor 2nd stage would involve bilateral laminectomy and excision of remaining soft tissues following by posterior instrumentation. Amputation technique resection of phalangeal or metacarpal lesions with ray transfer or allograft reconstruction Complications Malignant transformation to high grade sarcoma incidence very rare (<1% prevalence) latency 9 years from previous radiation treatment 19 years from spontaneous transformation treatment surgical resection of metastatic lesions interferon treatment radiation Secondary ABC incidence between 10-14% differentiate from primary ABC because of enhancing soft-tissue component in GCT (not present in primary ABC) Recurrence incidence local recurrence occurs in 20% cases diagnose with CT guided biopsy risk factors not using adjuvant treatment during surgery Pathologic fracture risk factors peri-articular lesions using crytherapy as an adjuvant Differentials & Groups IBank Location Xray Xray CT B. Scan MRI MRI Histo(1) Case A knee -recurrence Case B knee Case C distal radius Case D hand Case B knee Case B ankle Case A humerus (1) - histology does not always correspond to clinical case
QUESTIONS 1 of 35 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ13.233) A 38-year-old man presents with progressive wrist swelling and pain for 8 months as seen in Figure A. He underwent imaging and biopsy as seen in Figures B and C. What is the most appropriate treatment for this patient? Review Topic | Tested Concept QID: 4868 FIGURES: A B C Type & Select Correct Answer 1 Neoadjuvant chemotherapy, radical resection, and chemotherapy 4% (135/3310) 2 Neoadjuvant chemotherapy, radiotherapy, and wide resection 4% (117/3310) 3 Radiotherapy and wide resection 4% (125/3310) 4 Intralesional curettage and reconstruction with adjuvant treatments 87% (2888/3310) 5 Amputation 1% (26/3310) L 2 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review tested concept Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (SBQ12SP.76) A 55-year-old patient presents with lower lumbar back pain. A lateral radiograph of the L3 vertebral bone is shown in Figure A. Figure B and C are pre-operative biopsies. From the following options, what is the most likely diagnosis? Review Topic | Tested Concept QID: 3774 FIGURES: A B C Type & Select Correct Answer 1 Osteoblastoma 8% (222/2749) 2 Osteoblastic osteosarcoma 9% (237/2749) 3 Chondrosarcoma 18% (484/2749) 4 Ewing's Sarcoma 1% (41/2749) 5 Giant Cell Tumor 64% (1749/2749) L 3 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review tested concept (SBQ12SP.105) A 50-year-old female presents with the radiograph seen in Figures A through D. Which of the following should be obtained to complete initial workup of this patient? Review Topic | Tested Concept QID: 3803 FIGURES: A B C D Type & Select Correct Answer 1 MRI spine and brain 1% (10/1473) 2 Obtain skeletal survey 7% (102/1473) 3 SPEP and UPEP 2% (32/1473) 4 Mammogram 1% (17/1473) 5 CT chest 89% (1305/1473) L 1 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review tested concept Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ10.204) A 29-year-old female complains of increasing severity back pain for the past 4 months. Radiograph, CT scan, T1 and T2 MRI, and biopsy specimen are shown in Figures A through E. What is the most likely diagnosis? Review Topic | Tested Concept QID: 3297 FIGURES: A B C D E Type & Select Correct Answer 1 Osteosarcoma 4% (118/2690) 2 Ewing's sarcoma 2% (44/2690) 3 Lymphoma 2% (42/2690) 4 Giant cell tumor 58% (1571/2690) 5 Chordoma 34% (905/2690) L 4 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review tested concept (OBQ09.50) Which of the following radiographs demonstrates a tumor that would be best treated by curettage with a power burr and packing with cement? Review Topic | Tested Concept QID: 2863 FIGURES: A B C D E Type & Select Correct Answer 1 Figure A 5% (111/2160) 2 Figure B 2% (49/2160) 3 Figure C 1% (16/2160) 4 Figure D 0% (7/2160) 5 Figure E 91% (1969/2160) L 1 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review tested concept Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ08.252) A 33-year-old female reports lateral knee pain and slight fullness. She underwent a bone scan which showed increased activity isolated to the proximal fibula. Radiographs and histology are shown in Figures A and B. What is the most likely diagnosis? Review Topic | Tested Concept QID: 638 FIGURES: A B Type & Select Correct Answer 1 Parosteal osteosarcoma 1% (22/1748) 2 Eosinophilic granuloma 13% (224/1748) 3 Chondroblastoma 7% (124/1748) 4 Giant cell tumor 78% (1363/1748) 5 Multiple myeloma 1% (9/1748) L 2 Question Complexity A Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 4 Review tested concept Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ07.186) Giant cell tumors of bone can be locally aggressive and result in significant bone destruction. Which of the following is responsible for this type of bone destruction? Review Topic | Tested Concept QID: 847 Type & Select Correct Answer 1 Multinuclear giant cells 16% (227/1379) 2 Osteocytic stromal cells 3% (41/1379) 3 Tumor cell activation of osteoclasts 74% (1016/1379) 4 Tumor cell inactivation of osteoblasts 1% (16/1379) 5 Osteoprotegrin activation of osteoclasts 5% (74/1379) L 2 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review tested concept (OBQ07.197) A 40-year-old female presents with dull pain in her knee that has been increasing in severity over the past 6 months. Figures A through D show representative radiographs, MRI, and biopsy section. What is the most appropriate treatment? Review Topic | Tested Concept QID: 858 FIGURES: A B C D Type & Select Correct Answer 1 Observation 1% (15/1233) 2 Bone marrow biopsy 2% (25/1233) 3 Intra-lesional curettage with local adjuvant therapy 83% (1027/1233) 4 Neoadjuvant chemotherapy, surgical excision, and adjuvant chemotherapy 9% (115/1233) 5 Neoadjuvant radiotherapy and surgical excision 4% (44/1233) L 1 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review tested concept (OBQ06.73) A 41-year-old male presents with 6 months of wrist pain and swelling. He is otherwise healthy and denies trauma. Clincal photograph, radiographs, MRI, and histology are shown in Figures A through E. What is the most likely diagnosis? Review Topic | Tested Concept QID: 184 FIGURES: A B C D E Type & Select Correct Answer 1 Aneurysmal bone cyst 4% (53/1384) 2 Giant cell tumor 89% (1226/1384) 3 Telangectatic osteosarcoma 4% (61/1384) 4 High-grade osteosarcoma 2% (34/1384) 5 Osteomyelitis 0% (3/1384) L 1 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review tested concept (OBQ06.114) A 21-year-old man presents with a lytic lesion in his distal femur. A chest radiograph reveals a lung nodule. Which of the following tumors most likely to metastasize to lung ? Review Topic | Tested Concept QID: 300 Type & Select Correct Answer 1 Non-ossifying fibroma 1% (19/2377) 2 Giant cell tumor 93% (2222/2377) 3 Aneurysmal bone cyst 1% (23/2377) 4 Osteoid Osteoma 1% (35/2377) 5 Hemangioma 3% (71/2377) L 1 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 2 Review tested concept (OBQ05.203) All of the following locations are common sites for giant cell tumor of bone to occur EXCEPT? Review Topic | Tested Concept QID: 1089 Type & Select Correct Answer 1 Posterior elements of the spine 69% (580/840) 2 Distal femur 2% (14/840) 3 Sacrum 19% (162/840) 4 Distal radius 6% (50/840) 5 Proximal tibia 4% (31/840) L 3 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review tested concept (OBQ05.240) Giant cell tumors of bone can occur in many different areas throughout the body. All of the following are common locations for giant cell tumors of bone EXCEPT? Review Topic | Tested Concept QID: 1126 Type & Select Correct Answer 1 Sacrum 15% (90/588) 2 Distal radius 2% (10/588) 3 Tibial diaphysis 70% (410/588) 4 Distal femur 2% (14/588) 5 Phalanges of the hand 10% (61/588) L 2 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review tested concept (OBQ04.22) Figures A-E show skeletal distribution of common bone tumors. Which figure shows the most common sites of giant cell tumor distribution in bone? Review Topic | Tested Concept QID: 133 FIGURES: A B C D E Type & Select Correct Answer 1 Figure A 81% (1279/1571) 2 Figure B 3% (44/1571) 3 Figure C 5% (74/1571) 4 Figure D 7% (112/1571) 5 Figure E 4% (55/1571) L 2 Question Complexity B Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 1 Review tested concept
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