Introduction Metastatic cancer is the most common reason for a destructive bone lesion in adults carcinomas that commonly spread to bone include breast (16-37% of breast cancer patients develop spine mets) lung (12-15%) thyroid (4%) renal (3-6%) prostate (9-15%) Epidemiology incidence bone is the 3rd most common site for metastatic disease (behind lung and liver) demographics metastatic bone lesions are usually found in older patients (> 40 yrs) locations common sites of metastatic lesions include spine>proximal femur>humerus most common site of mets is spine thoracic spine is most common site of bony metastasis 2nd most common site of mets is proximal femur proximal femur is most common site of fracture secondary to metastatic bone lesions 65% nonunion rate 50% in femoral neck, 20% pertrochanteric, 30% subtrochanteric Pathophysiology mechanism of bone destruction (osteolysis) osteolytic bone lesions are caused by tumor induced activation of osteoclasts occurs through the RANK, RANK ligand (RANKL), osteoprotegrin pathway PTHrP positive breast cancer cells activate osteoblastic RANKL production osteoblastic bone metastases are due to tumor-secreted endothelin 1 Prognosis median survival in patients with metastatic bone disease thyroid: 48 months prostate: 40 months breast: 24 months kidney: variable depending on medical condition but may be as short as 6 months lung: 6 months Tokuhashi score (see classification section) Associated conditions metastatic hypercalcemia a medical emergency symptoms include confusion muscle weakness polyuria & polydipsia nausea/vomiting dehydration treatment hydration (volume expansion) loop diuretics bisphosphonates Principles of metastasis Mechanism of metastasis tumor cell intravasation E cadherin cell adhesion molecule (on tumor cells) modulates release from primary tumor focus into bloodstream avoidance of immune surveillance target tissue localization attaches to target organ endothelial layer via integrin cell adhesion molecule (expressed on tumor cells) extravasation into the target tissue induction of angiogenesis via vascular endothelial growth factor (VEGF) expression genomic instability decreased apoptosis Vascular spread Batson's vertebral plexus valveless venous plexus of the spine that provides a route of metastasis from organs to axial structure including vertebral bodies, pelvis, skull, and proximal limb girdles Mechanism of bone lysis oncogenic cell releases cytokines IL-6, IL-11, PTHrP, TGF-beta PTHrP and TGF-beta activate osteoblasts osteoblasts secrete RANKL, that binds to RANK on osteoclasts and activates osteoclasts Mechanism of bone sclerosis (prostate and breast mets) prostate cancer cells secrete endothelin 1 (ET-1) ET-1 binds to endothelin A receptor (ETAR) on osteoblasts and stimulates osteoblasts ET-1 decreasesWNT suppressor DKK-1 activates WNT pathway, increasing osteoblast activity Classification Tokuhashi score specific to metastatic disease to spine prognostic score based on 6 elements: general condition, extraspinal bony metastasis, number of vertebral bodies with metastasis, visceral metastasis, primary tumor, neurologic compromise score of 0-8: <6 months; 9-12 > 6 months, 12-15 >1 year Symptoms Symptoms pain axial night pain may be mechanical pain due to bone destruction or tumorigenic pain which often occurs at night metastatic hypercalcemia Physical exam neurologic deficits caused by compression of the spinal cord with metastatic disease to the spine Evaluation Workup for older patient with single bone lesion and unknown primary includes imaging AP and lateral of spine in region of pain CT of chest / abdomen / pelvis technetium bone scan to detect extent of disease myeloma and thyroid carcinoma are often cold on bone scan - evaluate with a skeletal survery labs CBC with differential ESR basic metabolic panel LFTs, Ca, Phos, alkaline phosphatase serum and urine immunoelectrophoresis (SPEP, UPEP) biopsy in patients where a primary carcinoma is not identified, obtaining a biopsy is necessary to rule out a primary bone lesion should not treat a bone lesion without tissue diagnosis of the lesion metastatic adenocarcinoma not identified by CT of the chest, abdomen, and pelvis is most likely from a small lung primary tumor See table of evaluation algorithms based on patient factors Imaging Radiographic recommended views AP and lateral of involved area off spine findings purely lytic or mixed lytic/blastic lesions lung, thyroid, and renal are primarily lytic 60% of breast CA is blastic 90% of prostate CA is blastic CT scan helpful to identify metastatic lesions to the spine MRI useful to show neurologic compromise of the spine Studies Histology characteristic findings epithelial cells in clumps or glands in a fibrous stroma immunohistochemical stains positive Keratin CK7 (breast and lung cancer) TTF1 (lung cancer) Treatment of Metastatic Lesions to Spine General considerations NOMS framework: neurologic, oncologic, mechanical instability, systemic illness neurologic: measure of epidural spinal cord compression (ESCC) 0-1 low grade, 2-3 high grade oncologic: responsiveness to radiation mechanical instability: spinal instability neoplastic score (SINS) SINS: 0-6 no surgical consultation required, 7-18 surgical consultation advisable systemic illness: formulation of prognosis from disease burden, medical comorbidities, functional status Nonoperative palliative care indications life expectancy of < 6 months Tokuhashi scoring system can be used to determine life expectancy radiation alone indications may be indicated in patients who are not surgical candidate Operative neurologic decompression, spinal stabilization, and postoperative radiation indications metastatic lesions to spine with neurologic deficits in patients with life expectancy of > 6 months technique preoperative embolization indicated in metastatic renal and thyroid CA to spine Complications Recurrence Hardware failure and spinal instability Nonunion of fracture
QUESTIONS 1 of 23 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Previous Next Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ12.162) A 62-year-old male patient presents with severe lower back pain radiating to his right lower abdomen and right leg. He previously underwent a right nephrectomy for renal cell carcinoma. On physical exam, he has weakness with right knee extension which is affecting his ability to ambulate. An MRI is performed and is shown in Figures A and B. Staging studies determine this to be an isolated metastatic lesion. What is the next best step in this patient's treatment? Review Topic QID: 4522 FIGURES: A B 1 Chemotherapy alone 1% (28/4280) 2 Radiation alone 3% (116/4280) 3 Vertebroplasty 1% (31/4280) 4 Embolization, surgical decompression and stabilization followed by radiation 88% (3755/4280) 5 Surgical decompression and stabilization followed by radiation 8% (329/4280) ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 4 Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ09.83) You are caring for a 63-year-old female with metastatic breast cancer to the lumbar spine. Her neurological examination shows significant weakness in leg function and she is having difficulty ambulating. Imaging shows significant neural element compression by the tumor and complete erosion of the L1 vertebrae. She has no other sites of metastatic disease and is otherwise healthy. What treatment option do you recommend to best maintain her function? Review Topic QID: 2896 1 Palliative therapy 1% (27/2551) 2 Complete neural element decompression 0% (11/2551) 3 Complete neural element decompression with instrumentation to stabilize the spine 9% (224/2551) 4 Complete neural element decompression, instrumentation, and postoperative chemotherapy 24% (613/2551) 5 Complete neural element decompression, instrumentation, and postoperative radiotherapy 65% (1670/2551) ML 3 Select Answer to see Preferred Response PREFERRED RESPONSE 5 (OBQ08.66) A 47-year-old female, otherwise in good general condition, has intractable back pain from metastatic breast cancer isolated to her spine. She has failed progressive multi-agent chemotherapy and hormone therapy. Her exam is normal except for slight sensory dysesthesia, hyperreflexic patellar tendons, and mild gait instability which she reports has been worsening. Cervical, thoracic, and lumbar MRI show an isolated metastatic lesion involving the T9 vertebral body with moderate cord compression of the ventral spinal cord. At this stage what is the best treatment? Review Topic QID: 452 1 Change chemotherapy protocol to Cyclophosphamide, Hydroxydanurubicin, Oncovin, Prednisone 1% (9/1179) 2 Posterior spinal decompression after vertebral body kyphoplasty 5% (59/1179) 3 Thoracic corpectomy, instrumented spinal fusion, and postoperative radiotherapy 83% (976/1179) 4 Radiation therapy 10% (123/1179) 5 Palliative care unit 1% (9/1179) ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 3 (OBQ12.124) A 68-year-old male presents to the emergency room with neck pain and progressive weakness to the point that he is unable to walk. Prior to this event he was in good health and active. On physical exam he is an ASIA C. Radiographs, computed tomography, and an MRI are show in Figure A,B, and C respectively. A CT of the chest, abdomen, and pelvis shows a single resectable lesion in the rectum consistent with a primary malignancy. Sagittal images of the spine show a single metastatic lesion in the thoracic spine, but no signs of thoracic canal compromise. He has no other metastatic bone lesions. What is the best treatment for this patient? Review Topic QID: 4484 FIGURES: A B C 1 Surgical decompression and stabilization followed by radiation 75% (2719/3637) 2 Radiation followed by surgical decompression and fusion 15% (538/3637) 3 Radiation alone 5% (184/3637) 4 Chemotherapy alone 1% (35/3637) 5 Palliative measures 4% (131/3637) ML 3 Select Answer to see Preferred Response PREFERRED RESPONSE 1 (OBQ08.204) A 67-year-old retired male custodian complains of progressively worsening low back pain over the past 6 months. He has not seen a doctor in the past 15 years. He admits to a 40 pack year smoking history, fatigue, and an unintentional 15 pound weight loss over the past year. A radiograph of the pelvis is provided in Figure A. Which of the following would most likely confirm the diagnosis? Review Topic QID: 590 FIGURES: A 1 Urine immunoelectrophoresis (UPEP) 12% (138/1118) 2 Thyroid biopsy 1% (9/1118) 3 CBC and blood smear 3% (32/1118) 4 Prostate biopsy 81% (904/1118) 5 Renal ultrasound 3% (29/1118) ML 2 Select Answer to see Preferred Response PREFERRED RESPONSE 4 (OBQ05.207) A 59-year-old female presents with a metastatic spinal tumor and has a lytic lesion in the T12 vertebral body. The process of bone resorption in her lytic lesion is mediated by Review Topic QID: 1093 1 Direct resorption of bone by tumor cells 2% (9/528) 2 Neoangiogenesis of the vertebral body 2% (8/528) 3 Macrophage-mediated bony destruction 6% (32/528) 4 Tumor induced activation of osteoclasts 89% (470/528) 5 Necrosis of the vertebral body 1% (5/528) ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 4 (OBQ09.51) A 59-year-old female with a history of biopsy proven metastatic renal cell carcinoma presents with a thoracic spine lesion consistent with renal cell carcinoma. She has lower extremity weakness and sustained clonus bilaterally. What is the most appropriate management prior to surgery? Review Topic QID: 2864 1 Blood cultures 0% (8/1997) 2 High dose IV methylprednisone 3% (50/1997) 3 Arterial embolization 90% (1792/1997) 4 CT guided cryotherapy 2% (42/1997) 5 Radiation therapy 5% (102/1997) ML 1 Select Answer to see Preferred Response PREFERRED RESPONSE 3 Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK
Login to View Community Videos Login to View Community Videos California Orthopaedic Association Annual Meeting - 2017 Current Approaches to Metastatic Bone Disease Anna Kulidjian, M.D. (COA 2017, 3.1) Anna Kulidjian Pathology - Metastatic Disease of Spine 4/12/2018 318 views Upgrade to View Premium Videos Upgrade to View Premium Videos oncology En Bloc Resection of Tumors of the Spine Mohammed Al Sobeai Pathology - Metastatic Disease of Spine 3/1/2017 226 views