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Review Question - QID 1130

QID 1130 (Type "1130" in App Search)
What is the most appropriate treatment for a 65-year-old female with a 100-pack-year tobacco history who presents with a new painful lytic lesion in her femoral diaphysis?

Antegrade femoral nailing with reamings sent to pathology for analysis

4%

97/2357

Antegrade femoral nailing with adjuvant radiotherapy to the lesion

2%

39/2357

Minimally invasive plating of the femur for stabilization and open cementation of the lesion

1%

17/2357

Referral to medical oncology for chemo-radiotherapy

2%

43/2357

Lesion biopsy with further treatment based on the results of the biopsy

91%

2143/2357

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New lesions which are not diagnosed by imaging and require surgical intervention need to have an appropriate biopsy with treatment dictated by the results of the biopsy. While this patient has a significant tobacco history, incorrect treatment of this lytic bone lesion could affect both her overall morbidity and mortality. As an example, a lytic high-grade chondrosarcoma may look exactly like a metastatic lesion but requires wide surgical excision, not just stabilization of an impending pathological fracture. Intramedullary nailing of a chondrosarcoma would spread the tumor the entire length of the bone and likely require a major amputation, not a limb salvage operation.

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