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A decrease in alkaline phosphatase would most likely be manifest in which metabolic disorder?
Familial hypocalciuric hypercalcemia
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Figure 11 shows the radiograph of a 2-year-old child with marked genu varum and tibial bowing. Based on these findings, what is the best initial course of action?
Obtain serum phosphorous, calcium, and alkaline phosphatase levels.
Obtain a scanogram to assess for limb-length discrepancy.
Perform bilateral valgus osteotomies to correct the deformities.
Measure the child for a varus prevention orthosis.
Educate the family about physiologic genu varum and conduct a follow-up examination in 6 months.
Hypophosphatasia is associated with which of the following laboratory findings?
Decreased urinary phosphoethanolamine
Decreased urinary inorganic pyrophosphate
Decreased serum phosphate
Decreased serum alkaline phosphatase