Summary Psoriatic Arthritis is a seronegative spondyloarthropathy that presents with DIP predominant arthritis of the hands, rash with silvery plaques, uveitis, and dysmorphic nails. Diagnosis is made based on a thorough evaluation of serum labs, clinical features, and radiographic findings. Treatment is usually medical management with a variety of options including corticosteroids, disease modifying anti-rheumatic drugs, and biological drugs. Epidemiology Incidence affect up to 5-20% of patients with psoriasis Demographics equally affects men and women Etiology Pathophysiology 5 patterns of arthritis asymmetric oligo/monoarticular arthritis affecting DIPJ, PIPJ, MCPJ DIP-predominant arthritis arthritis mutilans symmetric, RF-negative polyarthritis psoriatic spondyloarthropathy Genetics HLAB27 found in 50% Presentation Symptoms arthritic symptoms in hands Physical exam rash with silvery plaques over extensor surfaces (elbows, knees) typically precede joint involvement by several years (80-85% of time) hands dactylitis (sausage digit) onychodystrophy (nail pitting) onycholysis (lifting of nail plate starting distally) arthritis mutilans opera glass hands (la main en lorgnette) excess skin from the shortening of the phalanx bones becomes folded transversely, as if retracted into one another like opera glasses chronic uveitis entheses such as achilles tendonitis, posterior tibial tendonitis, and plantar fasciitis Imaging Radiographs hands distal phalanx acrolysis DIP arthritis classic finding is "pencil-in-cup" deformity simultaneous destruction of the head of the middle phalanx and expansion of the base of the distal phalanx different than DJD by presence of centripetal erosions which cause joint space widening small joint erosions or fusions (PIP, MCP, and wrist commonly involved) fluffy periostitis (caused by periosteal ossification) acroosteolysis (resorption of the distal phalanx tuft) flail digits spine in axial disease sacroiliitis syndesmophytes paravertebral ossification destructive discovertebral lesions Studies HLAB27 found in 50% RA and ANA tests are usually negative Treatment Nonoperative NSAIDS, methotrexate, sulfasalazine, cyclosporine,TNF-alpha inhibitors indications mainstay of treatment similar to RA Operative digit fusion vs resection arthroplasty indications advanced joint disease
QUESTIONS 1 of 4 1 2 3 4 Previous Next (OBQ17.129) A patient presents with the clinical images shown in Figures A-C. Which of the following is true? QID: 210216 FIGURES: A B C Type & Select Correct Answer 1 Most patients with this skin condition develop arthritis 19% (388/1995) 2 All patients that develop arthritis are positive for HLA-B27 7% (131/1995) 3 The skin lesions respond well to systemic anti-fungal therapy 1% (20/1995) 4 Rheumatoid factor and ANA are usually positive 18% (352/1995) 5 DIP erosions are often centripetal 54% (1079/1995) L 4 Question Complexity A Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review Tested Concept Review Full Topic Sorry, this question is for PEAK Premium Subscribers only Upgrade to PEAK (OBQ11.158) A 32-year-old man has a 10-month history of bilateral toe swelling and foot pain. A clinical photo showing his toes is shown in Figure A. On examination of his feet he has tenderness along the posterior tibial tendon bilaterally which worsens with single-leg heel rise maneuvers. Standing radiographs of the feet are normal without deformity of the lesser toes. A clinical photo of his fingernails are shown in Figure B. Which of the following diagnoses is MOST likely? QID: 3581 FIGURES: A B Type & Select Correct Answer 1 Pseudogout (chondrocalcinosis) 3% (102/3447) 2 Gout 3% (118/3447) 3 Psoriatic arthritis 83% (2855/3447) 4 Rheumatoid arthritis 1% (32/3447) 5 Scleroderma (systemic sclerosis) 10% (330/3447) L 1 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 3 Review Tested Concept Review Full Topic (OBQ10.241) A 47-year-old man complains of long standing pain involving the right index, middle, and ring fingers. A clinical image is shown in Figure A. A radiograph is provided in Figure B. Which of the following is the most likely diagnosis? QID: 3340 FIGURES: A B Type & Select Correct Answer 1 Gout 5% (78/1640) 2 Osteoarthritis 2% (35/1640) 3 Rheumatoid arthritis 6% (104/1640) 4 Septic arthritis 0% (3/1640) 5 Psoriatic arthritis 86% (1413/1640) L 1 Question Complexity C Question Importance Select Answer to see Preferred Response SUBMIT RESPONSE 5 Review Tested Concept Review Full Topic
All Videos (0) Podcasts (1) Basic Science⎪Psoriatic Arthritis Basic Science - Psoriatic Arthritis Listen Now 8:21 min 8/13/2020 60 plays 0.0 (0)