Updated: 6/17/2021

Synovium & Synovial Fluid

0%
Topic
Review Topic
0
0
0%
0%
Flashcards
3
N/A
N/A
Questions
2
0
0
0%
0%
Evidence
2
0
0
Topic
Images
https://upload.orthobullets.com/topic/9018/images/synovium.jpg
https://upload.orthobullets.com/topic/9018/images/screen_shot_2017-04-11_at_9.56.16_am.jpg
  • Synovium
    • Function
      • mediates nutrient exchange between blood and joint fluid
    • Composition
      • vascularized connective tissue is porous and lacks basement membrane
      • cell types
        • type A cells
          • derived from macrophages
          • non-fixed cells with antigen presenting ability
          • located in superficial layer
          • important in phagocytosis
        • type B cells
          • fibroblast like cells
          • rich rough endoplasmic reticulum and dendritic processes that reach out to the joint surface
          • located at various depths, frequently in deeper layer
          • produce synovial fluid
            • produce hyaluronic acid, fibronectin, collagen
        • type C cells
          • intermediate cell type
          • unknown function and origin
          • may serve as multi-potent precursor to either type A or B synovial cells
  • Synovial Fluid
    • Function
      • lubricates articular cartilage and provides nourishment through diffusion
    • Origin
      • made from a ultrafiltrate of blood plasma
        • regulated by synovium
          • healthy knee contains ~2mL of synovial fluid
    • Consists of
      • hyaluronin
        • uridine diphosphoglucose dehydrogenase enzyme critical for its synthesis
      • lubricin
        • a key lubricating glycoprotein
        • reduces coefficient of friction within the joint
      • proteinase
      • collagenases
      • prostaglandins
    • Biomechanics
      • synovial fluid exhibits non-Newtonian flow characteristics
        • the viscosity coefficient is not a constant
        • the fluid is not linearly viscous
        • viscosity increases as the shear rate decreases
Flashcards (3)
Cards
1 of 3
Questions (2)
Question locked
Sorry, this question is for
PEAK Premium Subscribers only
Upgrade to PEAK

(OBQ06.246) A healthy human knee normally contains approximately 2 milliliters of synovial fluid. What cell produces synovial fluid?

QID: 257
1

Type A synovial cell

23%

(563/2461)

2

Type B synovial cell

66%

(1627/2461)

3

Type C synovial cell

5%

(134/2461)

4

Chondrocyte

5%

(115/2461)

5

Fibrochondrocyte

0%

(12/2461)

L 3 D

Select Answer to see Preferred Response

Evidence (2)
VIDEOS & PODCASTS (1)
EXPERT COMMENTS (7)
Private Note