Updated: 8/3/2021

Squamous Cell Carcinoma

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summary
- Squamous Cell Carcinoma is a malignant soft tissue tumor most commonly found in elderly patients.
- Diagnosis is made with a biopsy.
- Treatment is wide surgical resection with or without radiation and skin grafting.

Epidemiology
- Anatomic location
  - dorsum of hand and forearm
  - most common subungual malignancy
- Riisk factors
  - primary risk factor is excessive exposure to ultraviolet radiation
  - actinokeratosis
  - chronic osteomyelitis
    
    Marjolin's ulcer is a squamous cell carcinoma resulting from chronic draining wounds or burn scars

Presentation
- Symptoms
  - pain

Imaging
- Radiographs
  - recommended views
    
    AP and lateral of affected area
  - findings
    
    lytic lesion

                        Differential
                    
                        Differential of Squamous Cell Carcinoma
                    
                        Treated with wide-resection alone
                    
                        Squamous cell
                    
                        o
                    
                        Adamantinoma
                    
                        o
                    
                        Chordoma
                    
                        o
                    
                        Chondrosarcoma
                    
                        o
                    
                        Parosteal osteosarcoma
                    
                        o

Treatment
- Operative
  - wide surgical resection +/-skin graft +/- radiation
    
    indications
    
    standard traditional treatment
    
    adjunctive radiation
    
    indications
    
    lesions >2cm wide
    
    4mm deep
    
    perineural invasion
    
    lymph node metastases
  - Mohs microsurgery
    
    indications
    
    becoming more popular
    
    smaller lesions
    
    highest cure rate
    
    technique
    
    lymph node biopsy may be necessary

Prognosis
- Metastasis
  - lymph node metastases and high histologic grade confer poor prognosis
  - higher metastatic potential than basal cell carcinoma

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Flashcards (1)

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Action	Numeric Key	Letter Key	Function Key
Show Bullets		S	Enter (frontside only)
20%	1	N
40%	2	H
60%	3	F	Enter (backside only)
80%	4	E
100%	5	M
Toss	0	T

Questions (4)

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(OBQ10.190) Which of the following best describes a squamous cell carcinoma that develops as a result of chronic drainage from sinus tracts or a result of burn scars?

QID: 3288

Type & Select Correct Answer

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Cushing's ulcer

(70/2314)

Mooren's ulcer

(30/2314)

Chancroid ulcer

(52/2314)

Marjolin's ulcer

88%

(2028/2314)