Updated: 8/3/2021

Squamous Cell Carcinoma

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  • summary
    • Squamous Cell Carcinoma is a malignant soft tissue tumor most commonly found in elderly patients.
    • Diagnosis is made with a biopsy.
    • Treatment is wide surgical resection with or without radiation and skin grafting.
  • Epidemiology
    • Anatomic location
      • dorsum of hand and forearm
      • most common subungual malignancy
    • Riisk factors
      • primary risk factor is excessive exposure to ultraviolet radiation
      • actinokeratosis
      • chronic osteomyelitis
        • Marjolin's ulcer is a squamous cell carcinoma resulting from chronic draining wounds or burn scars
  • Presentation
    • Symptoms
      • pain
  • Imaging
    • Radiographs
      • recommended views
        • AP and lateral of affected area
      • findings
        • lytic lesion
  • Differential
    • Differential of Squamous Cell Carcinoma
      Treated with wide-resection alone
      Squamous cell
      Adamantinoma
      Chordoma
      Chondrosarcoma
      Parosteal osteosarcoma
  • Treatment
    • Operative
      • wide surgical resection +/-skin graft +/- radiation
        • indications
          • standard traditional treatment
        • adjunctive radiation
          • indications
            • lesions >2cm wide
            • 4mm deep
            • perineural invasion
            • lymph node metastases
      • Mohs microsurgery
        • indications
          • becoming more popular
          • smaller lesions
          • highest cure rate
        • technique
          • lymph node biopsy may be necessary
  • Prognosis
    • Metastasis
      • lymph node metastases and high histologic grade confer poor prognosis
      • higher metastatic potential than basal cell carcinoma

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(OBQ10.190) Which of the following best describes a squamous cell carcinoma that develops as a result of chronic drainage from sinus tracts or a result of burn scars?

QID: 3288
1

Cushing's ulcer

3%

(69/2258)

2

Mooren's ulcer

1%

(29/2258)

3

Chancroid ulcer

2%

(51/2258)

4

Marjolin's ulcer

88%

(1976/2258)

5

Curling's ulcer

5%

(123/2258)

L 2 C

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