A 56-year-old construction worker who lives in El Paso presents with a large, indurated, scaly, erythematous lesion of the left hand. A clinical photo is depicting in Figure A. He reports this lesion appeared about 2 years ago and has progressively worsened over the last several months. A punch biopsy is performed with Figure B demonstrating the histologic findings. What is the most appropriate treatment option for this patient?