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A 56-year-old woman presents with a left gluteal mass. MRI is obtained and depicted in Figure A (T1-weighted). He undergoes a biopsy of the mass, and immunohistochemistry stains positive for the MDM2 amplification. Histology is depicted in Figure B. Which of the following is the best treatment?
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A 71-year-old male presents with a large mass on his right thigh. An MRI and biopsy are performed and are shown in Figures A-C. What is the genetic basis of the condition, and what is the next best step in treatment?
MDM2 amplification; marginal resection without radiation
t(2;13) translocation; marginal resection without radiation
MDM2 amplification; marginal resection with radiation
t(2;13) translocation; wide resection with radiation
t(12;16) translocation; wide resection with radiation
A 50-year-old male presents with a painless thigh mass that has been growing in size. A representative MRI sequence, gross specimen and histologic evaluation are shown in Figures A, B and C respectively. What is the most likely diagnosis and associated corresponding chromosomal translocation?
Alveolar rhabdomyosarcoma; t(2;13)
Pleiomorphic undifferentiated sarcoma; t(12;16)
Synovial sarcoma; t(X;18)
Myxoid liposarcoma; t(12:16)
Figures A, B, and C are the MRI scans and biopsy specimen of a 53-year-old man who has had left leg pain and swelling for the past 9 months. What is the most likely diagnosis?
Atypical lipomatous tumor
Pigmented villonodular synovitis
A 40-year-old female presents with a painless enlarging left thigh mass. Radiograph, T1, and T2 MRI images are shown in Figures A through C. Biopsy specimen is shown in Figure D. What is the most likely diagnosis?
A 56-year-old male presents with a mass in his thigh that has been slowly growing over the past year. Femur radiograph, sagittal T1 and T2 weighted MRI scans, and histology section taken from an open biopsy are shown in Figures A through D. What is the diagnosis?
Undifferentiated pleomorphic sarcoma