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Chondromyxoid Fibroma

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Topic updated on 11/10/12 1:30pm
Introduction
  • A very rare benign chondrogenic lesion characterized by variable amounts of
    • chondroid
    • fibromatoid
    • myxoid elements
  • Age & Location
    • usually located in long bones,
      • especially the tibia in metaphyseal areas
    • sometimes located in the foot
  • More common in males 
  • Genetics
    • may contain genetic rearrangement of chromosome 6 at postion q13
  • Metastasis
    • CMF is essentially a benign bone tumor and metastasis has not been reported.
  • Prognosis
    • prognosis is worse in children, with more lobulated tumor showing abundant myxoid material.
    • recurrence in CMF is not uncommon and has been described in up to 20%-30% cases.
Symptoms
  • Presentation
    • long standing pain
Imaging
  • Radiographs
    • lytic eccentric metaphyseal lesion that is sharply demarcated from adjacent bone
      • mineralization usually not present 
Histology
  • Classic characteristics are
    • low-power shows lobules of fibromyxoid tissue 
    • high power shows myxoid stroma with stellate cells 
    • giant cells may be present
  • Diagnosis
    • histopathologic examination is mandatory for confirmation of the diagnosis.
Treatment
  • Operative
    • intralesional curretage and bone grafting (or PMMA)
      • recurrence in 25%
Ibank
  Location
Xray
Xray
CT
B. Scan
MRI
MRI
Histo(1)
Case A foot
Case B tibia
Case C femur
Case D tibia
(1) - histology does not always correspond to case 

 

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