Is there an association between developing myositis ossificans and severe hypertonus following cerebral damage?Could Ibuprofene be used profylactically following resection of a myositis ossificans body?
All of the following statements regarding Paget's sarcoma are correct EXCEPT?
The 5-year survival for non-metastatic Paget's sarcoma is less than 5%
Less than 1% of patients with Paget's disease develop secondary Paget's sarcoma
While osteosarcoma is the most common histologic sub-type of Paget's sarcoma, fibrosarcoma and chondrosarcoma sub-types also occur
Paget's sarcoma typically occurs in patients over 50 years of age
Treatment of Paget's sarcoma is via surgery alone
Agree with the previous comment - I would like the authors to clarify the survival rate for metastatic and non-metastatic Paget's sarcoma, please.
Barrett's esophagus Pathology Lecture - Usmle Quick review
Barrett's esophagus - Usmle Quick reviewIn Barrett's esophagus, tissue in the tube connecting your mouth and stomach (esophagus) is replaced by tissue similar to the intestinal lining.Barrett's esophagus is most often diagnosed in people who have long-term gastroesophageal reflux disease (GERD) — a chronic regurgitation of acid from the stomach into the lower esophagus. Only a small percentage of people with GERD will develop Barrett's esophagus.Barrett's esophagus is associated with an increased risk of developing esophageal cancer. Although the risk is small, it's important to have regular checkups for precancerous cells. If precancerous cells are discovered, they can be treated to prevent esophageal cancer.
Zollinger-Ellison syndrome (ZES) - Animated lecture usmle step 1 pathology
Zollinger-Ellison syndrome is a rare condition in which one or more tumors form in your pancreas or the upper part of your small intestine (duodenum). These tumors, called gastrinomas, secrete large amounts of the hormone gastrin, which causes your stomach to produce too much acid. The excess acid then leads to peptic ulcers, as well as to diarrhea and other symptoms.Zollinger-Ellison syndrome (ZES) is rare. The disease may occur at any time in life, but people are usually diagnosed between ages 20 and 50. Medications to reduce stomach acid and heal the ulcers is the usual treatment for Zollinger-Ellison syndrome.SymptomsSigns and symptoms of Zollinger-Ellison syndrome may include:Abdominal painDiarrheaBurning, aching, gnawing or discomfort in your upper abdomenAcid reflux and heartburnNausea and vomitingBleeding in your digestive tractUnintended weight lossDecreased appetite
A 65-year-old man complains of deformity of the right leg. He denies pain at rest but does complain of ankle and lower leg pain when walking more than a half mile. A radiograph is shown in Figure A. Following 6 months of orthotic and brace treatment, he continues to struggle with pain. Which of the following is the best treatment option?
Continued orthotic and brace treatment
Corrective osteotomy and plate fixation
Corrective osteotomy, knee arthrodesis, and plate fixation
Dr. Almurabet - the first article below is an open access article, and the one following it is another one from JBJS Br that says free access as well. Hope those help.Modified Sofield-Millar operation: less invasive surgery of lower limbs in osteogenesis imperfecta.Abulsaad M, Abdelrahman AInt Orthop. 2009 Apr. doi: 10.1007/s00264-008-0515-1. 33. (2). :527-32PMID: 18283459 (Link to Abstract)The Sofield-Millar operation in osteogenesis imperfecta. A modified technique.Li YH, Chow W, Leong JCJ Bone Joint Surg Br. 2000 Jan. 82. (1). :11-6PMID: 10697308 (Link to Abstract)
Acromegaly and Gigantism - Pathology Usmle step 1 Lecture
Acromegaly and Gigantism - Pathology Usmle step 1 Lecture Development of abnormally large size due to the excessive growth of the long bones. Caused by hyperpituitarism before the completion of the normal ossification process (commonly seen in children). This is in contrast to acromegaly, which results from hyperpituitarism after the completion of the ossification process (commonly seen in adults). Typically accompanied by muscular weakness and sexual impotence. Most common cause is pituitary-associated gigantism.Acromegaly results from persistent hypersecretion of growth hormone (GH). Excess GH stimulates hepatic secretion of insulin-like growth factor 1 (IGF-1), which causes most of the clinical manifestations of acromegaly.The most common cause of acromegaly is a somatotroph (growth hormone [GH]-secreting) adenoma of the anterior pituitary. These adenomas account for about one-third of all hormone-secreting pituitary adenomasThe clinical features of acromegaly are attributable to high serum concentrations of both growth hormone (GH) and insulin-like growth factor 1 (IGF-1), which is GH-dependent. Excess GH and IGF-1 have both somatic and metabolic effects. The somatic effects include stimulation of growth of many tissues, such as skin, connective tissue, cartilage, bone, viscera, and many epithelial tissues.?The metabolic effects include nitrogen retention, insulin antagonism, and lipolysis.
Hypoparathyroidism Highyield lecture - Usmle step 1 pathology
Hypoparathyroidism occurs when there is destruction of the parathyroid glands surgical, autoimmune, abnormal parathyroid gland development, altered regulation of parathyroid hormone production, or impaired PTH action.
Craniopharyngioma ( High-yield Usmle step 1 pathology Lecture )
Craniopharyngioma--------------------------------A brain tumor arising from pituitary embryonic tissue. It is typically suprasellar and has solid and cystic components. Age of onset can occur in childhood (about age 10-15) or adulthood (about age 50-70). There are adamantinomatous, papillary, and mixed types. Adamantinomatous tumors are more common in children and papillary tumors are more common in adults. It is usually slow growing, and symptoms arise from compression of surrounding structures or increased intracranial pressure. Presenting symptoms include visual loss (most commonly superior temporal quadrantanopsia), headache, hormonal imbalances leading to delayed puberty in children, amenorrhea, hypersomnia, diabetes insipidus, and/or decreased libido. These tumors are usually benign with good prognosis, but often recur after incomplete resection.Best Tests------------------Head CT may show a solid and cystic mass, which can be bright in some types due to calcification.Brain MRI with and without gadolinium typically shows a suprasellar cystic lesion that enhances with contrast.Biopsy, usually done with tumor resection, confirms the diagnosis.
For the question, a 50 year old presents with a painful lytic lesion extending from the metaphysis to the epiphysis of the knee...presumed GCT. I understand that staging would be the next appropriate step, but staging for a 50 year old would consist of CBC, CMP, SPEP, UPEP, CT chest/abd/pelvis, bone scan. Is "MRI of the lower extremity" really part of the staging for a patient like this?
The Role of Denosumab in the Modern Treatment of Giant Cell Tumor of Bone
this a new review and update on the role of denusumab in GCT treatment. It can be used in unresectable tumors of the spine, sacrum, pelvis and challenging cases of upper and lower limb. Recurrence after cessation and conversion to pseudosarcomatous lesions are still uncertain.link to article:http://reviews.jbjs.org.proxy.bib.uottawa.ca/content/5/4/e4
Dr Ben .Where i can find more detail about Sofield technique.thank you.
A 62-year-old female sustained the injury seen in Figure A after a fall at home. Her past medical history is significant for mild hypertension only. She is not currently taking any medications. Her pre-operative assessment revealed elevated serum alkaline phosphatase. Serum calcium and phosphate were normal. What is the most likely underlying diagnosis?
Paget's bone disease
Aneurysmal bone cyst
Given the subtle lateral cortical flare, is this fracture a consequence of the disease (Paget's) or of bisphosphonate use in the treatment of symptomatic Paget's?
Telangiectatic osteosarcoma: a review of 87 cases
This is the largest telangiectatic osteosarcoma (TOS) series in the literature. It shows that TOS does not have poor prognosis. The 10 year survival was around 60%[PMLINK][PMTITLE]Telangiectatic osteosarcoma: a review of 87 cases.[/PMTITLE] [PMAUTH]Angelini A, Mavrogenis AF, Trovarelli G, Ferrari S, Picci P, Ruggieri P[/PMAUTH] [PMSRC]J Cancer Res Clin Oncol. 2016 Oct. doi: 10.1007/s00432-016-2210-8. pii: 10.1007/s00432-016-2210-8. 142. (10). :2197-207[/PMSRC] [PMID]27469493[/PMID][/PMLINK]
BMC Musculoskelet Disord. 2016 Apr 05;17:147. Epub 2016 Apr 5.
Dr. Irving - agree with your post. A nail is possible here with a Sofield technique, as I listed below. Another alternative would be an Ilizarov/TSF to provide slow correction of the deformity. I've updated the answer choice and added a bit to the discussion to minimize confusion with this question.
A 56-year-old male presents with a mass in his thigh that has been slowly growing over the past year. Femur radiograph, sagittal T1 and T2 weighted MRI scans, and histology section taken from an open biopsy are shown in Figures A through D. What is the diagnosis?
Undifferentiated pleomorphic sarcoma
Iso-intense ...to what?
Intralesional surgical resection is considered standard of care for which of the following conditions?
High grade sarcoma surrounding a major nerve
Intermediate grade solitary fibrous tumor
Atypical lipomatous tumor
Pigmented villonodular synovitis
unless you do the synovectomy without violating the tumor - I don't agree its marginal. I don't know how you couldn't cut into the synovium while taking it out - which by definition would make it intra-lesional. This is kinda splitting hairs tho, as all 4 other answers clearly require negative margin resections. As such, answer 5 is the best of the considered answers.
The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.
[PMLINK][PMTITLE]The stability of the hip after the use of a proximal femoral endoprosthesis for oncological indications: analysis of variables relating to the patient and the surgical technique.[/PMTITLE] [PMAUTH]Henderson ER, Keeney BJ, Pala E, Funovics PT, Eward WC, Groundland JS, Ehrlichman LK, Puchner SS, Brigman BE, Ready JE, Temple HT, Ruggieri P, Windhager R, Letson GD, Hornicek FJ[/PMAUTH] [PMSRC]Bone Joint J. 2017 Apr. pii: 99-B/4/531. doi: 10.1302/0301-620X.99B4.BJJ-2016-0960.R1. 99-B. (4). :531-537[/PMSRC] [PMID]28385944[/PMID][/PMLINK]
In the Differential & Groups table there is no mark in front of myeloma under chemo & radio therapy
J Pediatr Orthop. 2008 Jan-Feb;28(1):20-8.