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A healthy human knee normally contains approximately 2 milliliters of synovial fluid. What cell produces synovial fluid?
Type A synovial cell
Type B synovial cell
Type C synovial cell
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Synovial fluid is made by the fibroblast-like type B synovial cell. Type A synovial cells are important phagocytic cells. Recently a type C synovial cell has been identified and found to be an intermediate, non-functional cell, of unknown significance. Chondrocytes support the cartilage which immediately surrounds them. The fibrochondrocyte is the cell responsible for meniscal healing.
In their study, Schwarz and Hills describe the production of synovial fluid as the key function of the type B synoviocytes. In addition, they identified the role of proteolipids in boundary lubrication within synovial fluid and provide a comparison between the function of such proteolipids in the synovial fluid with their function in the lung. They hypothesize based on data presented in this study that exogenous administration of surface-active phospholipids may be beneficial in the treatment of arthritis.
Schwarz IM, Hills BA
Br. J. Rheumatol.. 1996 Sep;35(9):821-7. PMID: 8810664 (Link to Abstract)
Schwarz, BRJR 1996
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