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Which of the following tumors associated with the fusion protein SYT-SSX1 can metastasize via the lymph nodes?
Clear cell sarcoma
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A 29-year-old male presents with deep pain and swelling of the right foot. He first noticed pain and swelling 1 year ago, which has been steadily increasing over this time. He denies any recent trauma, travel or systemic symptoms. A radiograph of the foot is shown in Figure A. Figures B and C show images of an MRI scan of the right foot. A biopsy was performed as shown in Figure D. What is the most likely diagnosis?
Which of the following fusion proteins is associated with synovial sarcoma?
All of the following statements regarding synovial sarcoma are correct EXCEPT?
Typically occur around the joints of the upper or lower limb
Immunohistochemisty is positive for cytokeratin and epithelial membrane antigen
Histology is named because the cell line of origin is the type II synovial cell
May show biphasic or monophasic histology
Classic age range is the younger adult < 40 years of age
A 22-year-old female has a painful foot mass. Clinical photo, MRI, and histology slide are shown in Figures A through C. What is the most likely diagnosis?
The fusion gene resulting from the chromosomal translocation t(X;18)(p11;q11) is chararcteristically found in which malignancy?
Chronic myelogenous leukemia (CML)
Which of the following is the most common sarcoma found in the foot?
The chromosomal translocation t(X;18)is found in which of the following conditions?
A 33-year-old male presents with a painful mass in his axilla. Radiographs, MRI, and histology are shown in Figures A-C. The tumor stains positive for vimentin and epithelial membrane antigen on immunohistochemistry. What is the most likely diagnosis?
Malignant fibrous histiocytoma
Which of the following histology images represents a synovial sarcoma?