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A 40-year-old patient presents with a mass in the left great toe that has increased in size over the last several months. The patient denies any fevers or chills. Figure A demonstrates an AP radiograph of the left foot. Figure B is the biopsy of the lesion. Genetic analysis reveals an SYT-SSX1 fusion protein. Which of the following is true of this tumor compared to SYT-SSX2 translocation?
Smaller with less metastases
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Figures A through E represent histological images (low power, left; high power, right) of primary sarcomas of bone and soft tissue. Which of the following figures is characteristic of a t(X;18) translocation?
Which of the following tumors associated with the fusion protein SYT-SSX1 can metastasize via the lymph nodes?
Clear cell sarcoma
Which of the following fusion proteins is associated with synovial sarcoma?
All of the following statements regarding synovial sarcoma are correct EXCEPT?
Typically occur around the joints of the upper or lower limb
Immunohistochemisty is positive for cytokeratin and epithelial membrane antigen
Histology is named because the cell line of origin is the type II synovial cell
May show biphasic or monophasic histology
Classic age range is the younger adult < 40 years of age
A 22-year-old female has a painful foot mass. Clinical photo, MRI, and histology slide are shown in Figures A through C. What is the most likely diagnosis?
Which of the following is the most common sarcoma found in the foot?
The chromosomal translocation t(X;18)is found in which of the following conditions?
A 33-year-old male presents with a painful mass in his axilla. Radiographs, MRI, and histology are shown in Figures A-C. The tumor stains positive for vimentin and epithelial membrane antigen on immunohistochemistry. What is the most likely diagnosis?
Malignant fibrous histiocytoma
Which of the following histology images represents a synovial sarcoma?