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Osteosarcoma
4%
142/3712
Chondrosarcoma
5%
168/3712
Primary lymphoma of bone
11%
416/3712
Metastatic carcinoma
78%
2880/3712
Multiple myeloma
2%
87/3712
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The clinical presentation, radiographs, and histology are most consistent with metastatic carcinoma. Metastatic carcinoma is the most common cause of a destructive bone lesion in older adults. Bone is the third most common site of metastasis, behind the lung and liver. Osteosarcoma occurs predominately in the metaphysis, and is often associated with periosteal reaction. Patients with multiple myeloma will usually show elevated serum protein electrophoresis levels. The pathology slide shows a mixture of glandular cells and bone, representing metastatic gastric cancer. Osteosarcoma, chondrosarcoma, and primary lymphoma of bone lack the presence of glandular cells on histology.
4.2
(43)
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