Giant Cell Tumor of Tendon Sheath

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Topic updated on 10/23/12 7:25pm
  
Introduction
  • A benign nodular tumor that is found on the tendon sheath of the hands and feet                         
    • it is most common on palmar surface of radial three digits near DIPJ
  • Second most common soft-tissue tumor seen in the hand, following ganglion cyst
Presentation
  • Symptoms
    • enlarging mass
    • pain, worse with activity (or wearing shoes, for foot lesions)
  • Physical exam
    • firm, nodular mass that does not transilluminate
Imaging
  • Radiographs
    • pressure-type bone erosion can be seen in up to 5% of patients on radiographs 
  • MRI
    • MRI may be helpful diagnostically
    • appearance of the focal form is generally decreased signal intensity on both T1-and T2-weighted MR imaging 
Histology
  • Characterized by
    • proliferating histiocytes, moderately cellular (sheets of rounded or polygonal cells) 
    • hemosiderin (brown color) may be present, but typically less than seen with PVNS 
    • multinucleated giant cells are common
Treatment
  • Operative 
    • marginal excision
      • 5-50% recurrence rate
        • more common if tumor extends into joints and deep to the volar plate
        • local recurrence is usually treated with repeat excision
      • operative approach is dependant on location and extent of the tumor

 

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