Of the answers listed, only CBFA-1 has NO known role in the pathogenesis of Duputryen's contracture.
Dupuytren contracture, a disease of the palmar fascia, results in the thickening and shortening of fibrous bands in the hands and fingers. The offending cells are thought to be myofibroblasts and fibroblasts. Growth factors such as basic fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and transforming growth factor-beta (TGF-beta) may signal the overproduction of the myofibroblasts and/or myofibroblastic activity of the fibroblasts. In addition, high levels of TGF-Beta may hinder apoptosis of the active myofibroblasts, unlike normal tissue healing.
McGrouther discusses how the pathophysiology of Dupuytren's is related to the anatomy of the palmar ligaments. The article discusses the proposed etiology of Dupuytren's with a loss of normal motion between palmar fascial ligaments causes stress concentrations which stimulate fibrous tissue deposition and contracture.
Baird et al performed a tissue analysis of 12 patients with Dupuytren's contracture compared to 12 control patients. They found that Dupuytren's expressed a higher percentage of peptide regulatory factors including interleukin-1 alpha, interleukin-1 beta, transforming growth factor beta, and basic fibroblast growth factor.
Trumble TE (ed): Hand Surgery Update 3: Hand, elbow, & shoulder. Rosemont, IL, American Society for Surgery of the Hand, 2003, pp 393-401
McGrouther DA: The microanatomy of Dupuytren's contracture. Hand 1982,14:215-236
PMID:7152372 (Link to Abstract)
Baird KS, Crossan JF, Ralston SH. Abnormal growth factor and cytokine expression in Dupuytren's contracture. J Clin Pathol. 1993 May;46(5):425-8.
PMID:8320323 (Link to Abstract)