Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
Figure A
13%
259/2048
Figure B
3%
60/2048
Figure C
77%
1583/2048
Figure D
2%
44/2048
Figure E
4%
92/2048
Select Answer to see Preferred Response
This patient's radiograph is suggestive of a giant cell tumor with bone destruction. Figure C demonstrates multinuclear giant cells, which are the hallmark of this lesion. A Giant Cell Tumor (GCT) is a benign aggressive tumor typically found in the metaphysis of long bones, often around the knee in young adults. This destruction is caused by the tumor cell activation of the osteoclasts and the secondary osteoclast resorption of bone. Histologically, numerous multinuclear giant cells are the hallmark of this lesion. Treatment is generally curretage, adjuvant treatment, and reconstruction as necessary depending on location of lesion. Raskin et al. reviews giant cell tumor (GCT) of bone. They report that this benign mesenchymal tumor has characteristic multinuclear giant cells and mononuclear stromal cells are the physiologically active and diagnostic cell type. Turcotte et al. reviews giant cell tumor. The report that this is a common benign bone tumor that has a strong tendency toward local recurrence and the rare capacity to metastasize to the lungs. Preferred treatment usually consists of extensive curettage and filling of the cavity with bone graft or cement. Figure A is the histology of a Ewing's sarcoma with small round blue cells. Figure B is the histology of a myxoid liposarcoma. Figure C is the histology of a giant cell tumor demonstrating multiple multinuclear giant cells. Figure D is the histology of a lipoma demonstrating adipocytes. Figure E is the histology of a neurilemmoma demonstrating Antoni A and B regions. Figure F is the AP radiograph of the knee demonstrating a giant cell tumor with bone destruction. Illustration A show the complex interaction between the tumor cells, osteoclast precursors, and the activated osteoclast actively resorbing bone. Illustration B shows the effects of OPG which decreases tumor induced osteolysis by blockade of the RANK to RANKL interaction. Illustration C shows a giant cell tumor of the proximal tibia in the epiphysis demonstrating tumor induced osteolysis caused by the neoplastic cell activation of local osteoclasts. Incorrect Answers: Answer 1: This is the histology of Ewing's sarcoma Answer 2: This is the histology of myxoid liposarcoma Answer 4: This is the histology of a lipoma Answer 5: This is the histology of neurilemmoma
2.6
(24)
Please Login to add comment