Review Question - QID 8343

A 68-year-old woman with a 9-year history of type II diabetes is seen 11 weeks after an uncemented left total hip replacement. When seen 6 weeks after surgery, some mild erythema and induration at the distal incision was noted, but no drainage. She states that drainage started 2 weeks ago. Examination shows turbid drainage coming from the distal third of the incision with mild surrounding erythema. Hip range of motion causes mild discomfort. Investigations reveal an erythrocyte sedimentation rate of 45 mm/h (reference range, 0-20 mm/h) and C-reactive protein of 54 mg/L (reference range, 0.08-3.1 mg/L). A rapid polymerase chain reaction of the swabbed fluid is positive for methicillin-resistant Staphylococcus aureus. Hip aspiration under fluoroscopy is attempted but no fluid is obtained. What is the most appropriate treatment?