Review Question - QID 703

The patient has symptoms, radiographs, and histology consistent with an adamantinoma. Adamantinomas are rare tumors of long bones that can be mistaken for a carcinoma and other lesions such as myoepithelial tumor, malignant mixed tumor of bone, fibrous dysplasia/osteofibrous dysplasia, and vascular tumors. The histology often reveals epithelial islands with basaloid, spindle, and squamous features on a background of fibrotic stroma. The article by Desai is a study of 12 adamantinoma cases in which radiologically the tumor presented as a lytic, eccentric, intracortical lesion in the tibia. The histology revealed epithelial islands with basaloid, spindle, and squamous features on a background of fibrotic stroma. The article by McCaffrey analyzed 3 osteofibrous dysplasia patients because diagnosis and treatment are complicated by the fact that osteofibrous dysplasia can resemble monostotic fibrous dysplasia and adamantinoma of long bones grossly and microscopically and that it tends to recur if surgical intervention is performed before skeletal maturity is reached.