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Altered parathyoid hormone receptor sensitivity
27%
548/2056
Chronic metabolic alkalosis
4%
73/2056
Chronic imbalance of electrolytes during dialysis
87/2056
Uremia related phosphate retention
59%
1219/2056
Tyrosine kinase receptor phosphorylation of the improper intracellular signalling proteins
6%
115/2056
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The key pathophysiological step in renal osteodystrophy is uremia related phosphate retention. While the pathogenesis is multifactorial, renal osteodystrophy is characterized by bone mineralization deficiency due to the electrolyte and endocrine abnormalities associated with chronic kidney disease. Hypocalcemia occurs due to the inability of the damaged kidney to convert vitamin D3 into its active form calcitriol. The damaged kidneys are also not able to adequately secrete phosphorus. This causes insoluble calcium phosphate to form in the body which removes calcium from the circulation. This leads to hypocalcemia and hence secondary hyperparathyroidism, along with hyperphosphatemia.
3.3
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