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Their sons will have a 50% chance of having this X-linked dominant disorder.
21%
51/239
All of their daughters will be carriers or will have this disorder.
58%
138/239
They should be advised to not have any children as the risk of having boys with the disorder and girls who will be carriers is too hard for any parent.
1%
3/239
As long as the woman does not carry the trait, the children will not be affected because the husband has the disease and this is an X-linked dominant disorder.
11%
26/239
Their sons or daughters may be born with this disorder, but males are more severely affected.
8%
18/239
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Hypophosphatemia is a rare genetic disease usually inherited as an X-linked dominant trait. The fact that the woman has no skeletal manifestations would indicate that the husband has the X-linked mutation. The disease is more severe in boys than it is in girls. The husband will not transmit the disease to his sons. However, all of their daughters will be affected either with the disease or as carriers. If the woman has the disease or the trait, there is a 50% chance that her sons will inherit the disease and a 50% chance that her daughters will be carriers or have a milder form of the disease. Parents should be advised to have genetic counseling so they can be informed when deciding whether to have children.
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