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IV
1%
11/746
V
6%
44/746
VI
8/746
VII
82%
614/746
VIII
8%
61/746
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Warfarin acts by inhibiting clotting factors II, VII, IX, X. The actual mechanism of action is by inhibition of hepatic enzymes, vitamin K epoxide, and perhaps vitamin K reductase. This inhibition results in lack of carboxylation of vitamin K-dependent proteins (II, VII, IX, X). The anticoagulant effect of warfarin can be reversed with vitamin K or fresh-frozen plasma. The use of alcohol may lead to liver dysfunction and an even more limited margin of available factors.
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