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Using commercially available antibiotic-loaded bone cement
4%
48/1069
Adding 0.5 g vancomycin to commercially available antibiotic-loaded bone cement
41/1069
Adding 0.5 g tobramycin and 0.5 g vancomycin/unit of standard bone cement
8%
90/1069
Adding either 1.0 g vancomycin or 1.2 g tobramycin per 40 g of standard bone cement
36%
387/1069
Adding a minimum of 3.6 g tobramycin and 1.0 g vancomycin per 40 g of bone cement
46%
496/1069
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In a review of the practical applications of antibiotic-loaded bone cement for the treatment of the infected total joint arthroplasties, Hanssen and Spangehl described commercially available antibiotic-loaded bone cement as low-dose antibiotic cements. These cements generally contained 0.5 g of either tobramycin or gentamicin per 40 g of cement. They are indicated for use in prophylaxis and not for treatment of infected total joint arthroplasties. High-dose antibiotic-loaded bone cements are described as those containing greater than 1.0 g of antibiotic per 40 g of cement. Effective elution levels have been documented with 3.6 g tobramycin and 1.0 g vancomycin per 40 g of bone cement. This was documented by Penner and associates. Furthermore, it was shown that the combination of the two antibiotics in the bone cement improved the elution of both antibiotics.
1.9
(20)
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