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Baseline serum ion levels increase with increasing activity levels.
25%
193/769
The risk of cancer is substantially increased.
1%
6/769
Linear ion production increases over time.
18%
135/769
Ions produced are excreted primarily through the kidney.
52%
400/769
Nickel is the most prevalent ion released into circulation.
4%
29/769
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Activity levels do not affect cobalt and chromium ion levels, which are the bulk of serum ion levels. The majority of ions are produced in the run-in period in the first several years. A gradual reduction in ion levels occurs thereafter. The kidneys are responsible for the bulk of clearance from the serum, and to date there is no relationship of cancer to ion levels in the serum.
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