Select a Community
Are you sure you want to trigger topic in your Anconeus AI algorithm?
You are done for today with this topic.
Would you like to start learning session with this topic items scheduled for future?
The patient is at a significantly higher risk of surgical infection
32%
1349/4209
The patient is more likely to be of African than of European descent
46%
1921/4209
The patient is more likely to be of European than of Middle Eastern descent
13%
558/4209
The patient is more likely to be a non-athlete than an athlete
2%
80/4209
The patient is more likely to be female than male
6%
272/4209
Select Answer to see Preferred Response
The clinical presentation is consistent with Benign Ethnic Neutropenia, a condition in which a patient has chronic, benign, inborn and lifelong absolute neutrophl count below population mean. This condition is found in the U.S. to be most common in African-Americans, some groups of Middle Eastern patients, males, children under 5 years old, and athletes compared to non-athletes. A standardized level at present for abnormally low absolute neutrophil count (ANC) is below 1.5 x 10(9) cells/L, however this may not have clinical or scientific relevance as a cutoff point, particularly in the affected Ethnic groups. Fewer than 1% of all populations have absolute neutrophil count < 1.0 X 10(9) cells/L. Most patients in the affected ethnic groups with low ANC and no associated history or symptoms are not expected to have any increased risk of infection or adverse effect. Smoking was also associated with higher leukocyte and neutrophil counts but proportionately lower increase in African-American patients. One hypothesis for the increased prevalence of B.E.N. in patients of African descent is a theorized evolutionary protection against malaria, though it remains unclear if this is causal or just correlative. Haddy et al. provide an excellent scientific review of B.E.N. and emphasize the importance of recognizing this most common form of neutropenia. Eichner et al. review B.E.N. in the setting of sports medicine and state the relative increase of these lab findings in athletes vs non-athletes. Hsieh et al. provide an extensive cross-sectional population study focused on the prevalence of Benign Ethnic Neutropenia in the U.S. They reviewed 25,222 participants in the National Health and Nutrition Examination Survey 1yr of age or older from 1999-2004, and detail the association of this condition with age, sex, ethnicity, and smoking status. Denic et al. analyzed neutrophil count in a healthy Arab population in the U.A.E. and found low neutrophil counts in this population with a distribution suggestive, but not definitively, of an autosomal dominant inheritance. They also discuss the hypothesized association of B.E.N. and malaria infection. Incorrect answers: Answer 1. In the absence of other clinical findings, B.E.N. is not believed to increase risk of surgical infection. Answer 3. Benign Ethnic Neutropenia is more common in some Middle Eastern sub-populations than patients of European descent Answer 4. Benign Ethnic Neutropenia is more common in athletes. Answer 5. Benign Ethnic Neutropenia is more common in males.
1.3
(63)
Please Login to add comment