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Review Question - QID 4530

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QID 4530 (Type "4530" in App Search)
Which of the following procedures has been found to lead to accelerated disc degeneration and the development of reactive endplate changes?

Provocative discography

86%

4606/5345

Lumbar myelogram

2%

82/5345

Cervical myelogram

1%

39/5345

Lumbar transforaminal epidural steroid injections

10%

549/5345

Lumbar spinal anesthesia

1%

35/5345

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Provocative discography leads to accelerated disc degeneration and the development of reactive endplate changes.

The diagnosis and treatment of discogenic pain remains controversial. Provocative discography is the primary method to confirm the diagnosis of discogenic pain. In this procedure, contrast is injected into the nucleus pulposus in the affected disc as well as a normal adjacent levels as a control. If the injection into the affected disc reproduces pain, and the injection in the adjacent control level does not reproduce pain, the provocative discography is considered positive.

Carragee et al. performed a prospective study of disc degeneration progression over 10 years with and without baseline discography. They found discs that had been exposed to discography had greater progression of degenerative findings compared to control (noninjected) discs. Degenerative changes included new disc herniations, decreased disc height, and endplate changes.

Kim et al. used a rabbit model to evaluate the effect of puncturing the intervertebral disc annulus with different gauged needles. They found that puncturing the annulus with a needle consistently led to disc degeneration in the rabbit lumbar spine.

Illustration A shows an example of a 3 level provocative discography.

Incorrect Answers:
Answer 2,3,4,5: None of these procedure have been shown to directly lead to accelerated degenerative changes of the intervertebral disc.

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