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They are activated by chelating agents
5%
286/5250
They mediate the destruction of cartilage in septic arthritis
77%
4025/5250
Toll-like receptors inhibit the formation of MMPs
6%
336/5250
They have a anabolic effect on cartilage
277/5250
Stromelysin is an indirect antagonist of many MMPs
268/5250
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Matrix metalloproteinases have been associated with the destruction of cartilage in septic arthritis. Matrix metalloproteinases and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), are crucial to extracellular matrix remodeling in normal tissue development and maintenance. Additionally, their over-expression has been associated with cartilage degradation in diseases such as rheumatoid arthritis, osteoarthritis, and septic arthritis. In septic arthritis, toll-like receptors activate the NF-kB pathway which leads to the production of MMPs and resulting cartilage destruction. Papathanasiou et al. investigate the role of toll-like receptors in septic arthritic chondrocytes. They demonstrated that TRL-1, 2, and 6 were up-regulated in septic chondrocytes and that TRL-2 directly affects the NF-kB pathway that leads to the production of MMPs. Illustration A shows the pathway through which MMPs work to destroy cartilage. Incorrect Answers: Answer 1: Chelating agents bind to metals that serve to activate MMPs, thus inactivating them. Answer 3: Toll-like receptors have been linked to the NK-kB pathway, which activates the formation of MMPs. Answer 4: MMPs have a catabolic effect on cartilage. Answer 5: Stromelysins are a subgroup of matrix metalloproteinases.
2.8
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