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15-year-old girl with bone forming distal femoral lesion on radiographs
11%
283/2474
7-year-old boy with lipomatous lesion in his proximal thigh
4%
97/2474
3-year-old boy with pituitary intracranial mass
7%
177/2474
5-year-old girl with lytic diaphyseal femur lesion positive for the EWS-FLI1 transgene
66%
1645/2474
12-year-old boy with shepard's crook deformity of his proximal femur and deactivating mutation in the G-beta subunit of the G-protein coupled receptor.
10%
254/2474
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Bone marrow biopsy for musculoskeletal sarcomas is only routinely done for Ewing’s sarcoma. Ewing’s sarcoma falls in the group of small round blue cell tumors, and while there is argument regarding the cell origin for Ewing’s, most agree that the cell of origin develops in the bone marrow. In addition to the normal tumor staging, Ewing’s sarcoma requires a bone marrow biopsy at a distant site to ensure no marrow metastasis - which would change the patient’s prognosis. Carvajal et al. discuss the neuroectodermal family of tumors, including Ewing's sarcoma, and specifically discuss hematopoetic development/transformation, diagnosis, treatment, and outcomes. Incorrect Answers: Patient’s with osteosarcomas, lipomas, crainiopharyngioma, and fibrous dysplasia typically do not require a bone marrow biopsy.
3.6
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