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Review Question - QID 3493

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QID 3493 (Type "3493" in App Search)
Which of the following antibiotic families inhibit bacterial DNA gyrase?

Quinolones

81%

2249/2793

Penicillins

1%

26/2793

Aminoglycosides

11%

307/2793

Macrolides

5%

142/2793

Sulfonamides

2%

49/2793

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Quinolones are a class of antibiotics which act by inhibition of bacterial DNA gyrase. Penicillins interfere with bacterial cell wall synthesis. Aminoglycosides and macrolides interfere with bacterial protein synthesis by acting on the 30S and 50S ribosome subunits respectively. Sulfonamides interfere with bacterial folic acid metabolism.

Levine and DiBona review fluoroquinolones as a class of antibiotics and describe their potential beneficial and adverse effects in the treatment and prevention of musculoskeletal infections. While not frequently used in musculoskeletal infection, fluoroquinolones appear to be very effective in the treatment of osteomyelitis and infections involving prosthetic implants like hip and knee replacements.

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