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Chondrosarcoma
4%
127/3455
Osteosarcoma
52%
1789/3455
Spindle cell sarcoma of bone
3%
92/3455
All of the above
37%
1288/3455
None of the above
147/3455
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Patients with Paget's disease are predisposed to secondary osteosarcoma, chondrosarcoma, and spindle cell sarcoma of bone (e.g. fibrosarcoma) all which can occur through Pagetoid lesions. Huvos describes their clinical analysis of 117 patient older than 60 years of age with osteoarcoma and found that this population developed sarcomas more frequently related to other preexisting bone conditions, such as Paget's disease or following irradiation. Five-year survival for this patient cohort was related to the development of primary (37%) vs. secondary osteosarcoma associated with other skeletal conditions (7.5%).
3.0
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