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RANK
17%
543/3261
RANK-ligand
76%
2473/3261
OPG-receptor
6%
209/3261
CD7
0%
10/3261
CD10
13/3261
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Osteoprotegrin (OPG) binds to RANK ligand (RANKL) to inhibit it from binding to RANK which are present on osteoclast-precursor cells. Normally, RANKL interacts with RANK to stimulate activation of osteoclasts. Jacobs et al present a nice review of the cellular and chemical mediators of osteolysis. Illustration A demonstrates the interaction between OPG, RANK, and RANKL during osteoclast differentiation.
4.3
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