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Review Question - QID 220073

QID 220073 (Type "220073" in App Search)
A 74-year-old female with a history of rheumatoid arthritis presents to the clinic for a second opinion regarding her painful total hip arthroplasty. She had a metal-on-metal hip placed 15 years ago by an outside surgeon. She now presents with pain and loss of motion. Radiographs obtained confirm a metal-on-metal total hip prosthesis without any radiographic evidence of loosening or fracture. An MRI demonstrates a large fluid collection consistent with adverse local tissue reaction (ALTR). Her laboratory results are as follows:

Serum ESR: 34 mm/hr
Serum CRP: 12 mg/L
Serum cobalt: 14 ppb
Serum chromium: 11 ppb
Synovial WBC count: 4,100 WBC/µL
Synovial alpha-defensin: +

You would like to rule out prosthetic joint infection (PJI) before revision surgery. Which of the following is true regarding the diagnostic workup of this patient?