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Primary cell type in cell-mediate immune response
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Express major histocompatibility complex (MHC) molecules on cell surface
They secrete RANKL
Bind to IgE-antigen complex
Express CD3 surface marker
Select Answer to see Preferred Response
Aseptic loosening occurs through four main steps: (1) particulate debris formation; (2) macrophage activated osteoclastogenesis and osteolysis; (3) prosthesis micromotion; (4) particulate debris dissemination. The most commonly particulate generated through adhesive wear following a TKA is UHMWPE. Macrophage phagocytize the wear particles and debris and subsequently release several cytokines including TNF-a. Macrophages are the predominant cell type that initiate the inflammatory cascade eventually resulting in osteolysis. Incorrect Answers:Answer 1: Cytotoxic T cells are the predominant cell type involved in cell-mediate immune response. Answer 3: RANKL is secreted by osteoblasts. Answer 4: Mast cells bind to IgE-antigen complex via FcεRI receptor, which is primarily responsible for allergic responseAnswer 5: CD3 cell surface maker are expressed on T-cells
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