Review Question - QID 218240

A 61-year-old male presents to your office with complaints of right knee pain, which has been progressive for several months. The pain is primarily present over the medial joint line and is worse with weight-bearing activities. Radiographs demonstrate moderate to severe osteoarthritis of his knee with approximately 5º of varus deformity. He has not previously had any treatment but states his quality of life is now being affected. What treatment strategy would you most strongly recommend to manage his pain and dysfunction based on current guidelines?