Review Question - QID 218212

A 68-year-old male is brought to the operating room for revision of a total knee arthroplasty (TKA). The patient is 7 years status-post his index procedure. Preoperative evaluation and intraoperative findings are consistent with aseptic loosening. The patient is 130 kg and has a negative preoperative nasal MRSA screen. He reports being told as a child that he is allergic to cephalosporin antibiotics, but cannot state what reaction he exhibits. Due to his cardiac history, you plan on admitting the patient for at least 24 hours following surgery. Which of the following statements is most accurate regarding the optimal antibiotic prophylaxis for this patient?