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Review Question - QID 215778

Antibiotic Classification & Mechanism QID: 215778 (SBQ20BS.12)
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QID 215778 (Type "215778" in App Search)
A 28-year-old male IV drug user presents to the ED with a forearm abscess after injecting heroin. Incision and drainage is performed and cultures reveal Methicillin-sensitive Staphylococcus Aureus (MSSA). He is treated with intravenous Cefazolin and transitioned to oral Cephalexin as an outpatient. He returns to the ED 2 months later with a similar forearm abscess. Repeat incision and drainage is performed and cultures/sensitivities are again obtained. Staphylococcus aureus is identified, however, it is now resistant to Methicillin and several other penicillins and cephalosporins. What is the primary mechanism by which this antibiotic resistance develops?
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