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Review Question - QID 1304

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QID 1304 (Type "1304" in App Search)
Which of the following statements best describes a plasmid?

An extrachromosomal, circular piece of DNA that replicates independently of host DNA

85%

899/1060

An extrachromosomal, linear piece of RNA which replicates independently of host DNA

9%

96/1060

A protein which promotes transcription of DNA to RNA

4%

47/1060

A gene which leads to cancerous cell transformation

1%

7/1060

A gene which suppresses cancerous cell transformation

0%

5/1060

Select Answer to see Preferred Response

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A plasmid is an extrachromosomal circular piece of DNA that replicates independently of host DNA.

In nature, plasmids frequently carry genes that may benefit the survival of the organism, such as antibiotic resistance genes. Artificially, plasmids are frequently used as vectors to introduce genes into a cell and change genetic expression. This has potential therapeutic benefits for the treatment of arthritis and bone healing.

Whalen et al. discuss various methods for transferring therapeutic genes into an arthritic joint. These include gene transfer through a vector inserted directly into a joint, and indirect transfer where synovial cells are isolated and genetically modified using vectors, then transplanted back into the joint.

Lieberman et al. present a review discussing the potential future benefits of gene transfer in bone healing, spine fusion, and articular cartilage repair.

Illustration A shows a visual representation of a plasmid. Note how the plasmid is extrachromosomal and the structure is identical to that of the host DNA. Video V is an educational video that gives an overview on plasmids.

Incorrect Answers:
Answer 2: A plasmid is a small piece of DNA, not RNA.
Answer 3: This defines a trancription factor.
Answer 4: This defines an oncogene.
Answer 5: This defines a tumor suppressor gene.

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