Introduction Definition degenerative disease of synovial joints that causes progressive loss of articular cartilage Epidemiology incidence hip OA (symptomatic) 88 per 100,000 per year knee OA (symptomatic) 240 per 100,000 per year Risk factors modifiable articular trauma muscle weakness heavy physical stress at work high impact sporting activities non-modifiable gender females >males increased age genetics developmental or acquired deformities hip dysplasia slipped capital femoral epiphysis Legg-Calvé-Perthes disease Pathophysiology pathoanatomy articular cartilage increased water content alterations in proteoglycans eventual decrease in amount of proteoglycans collagen abnormalities organization and orientation are lost binding of proteoglycans to hyaluronic acid synovium and capsule early phase of OA mild inflammatory changes in synovium middle phase of OA moderate inflammatory changes of synovium synovium becomes hypervascular late phases of OA synovium becomes increasingly thick and vascular bone subchondral bone attempts to remodel forming lytic lesion with sclerotic edges (different than bone cysts in RA) bone cysts form in late stages Cell biology proteolytic enzymes matrix metalloproteases (MMPs) responsible for cartilage matrix digestion examples stromelysin plasmin aggrecanase-1 (ADAMTS-4) tissue inhibitors of MMPS (TIMPs) control MMP activity preventing excessive degradation imbalance between MMPs and TIMPs has been demonstrated in OA tissues inflammatory cytokines secreted by synoviocytes and increase MMP synthesis examples IL-1 IL-6 TNF-alpha Genetics inheritance non-mendilian genes potentially linked to OA vitamin D receptor estrogen receptor 1 inflammatory cytokines IL-1 leads to catabolic effect IL-4 matrilin-3 BMP-2, BMP-5 Presentation History identify age, functional activity, pattern of arthritic involvement, overall health and duration of symptoms Symptoms function-limiting hip pain effect on walking distances pain at night or rest hip stiffness mechanical instability, locking, catching sensation Physical exam inspection body habitus gait leg length discrepancy skin (e.g. scars) range of motion lack of full extension (>5 degrees flexion contracture) lack of full flexion (flexion < 90-100 degrees) limited internal rotation Neurovascular exam straight leg test negative Imaging Radiographs recommended views standing AP pelvis AP + lateral hip optional views false profile view (e.g. hip dysplasia) findings osteoarthritis joint space narrowing osteophytes subchondral sclerosis subchondral cysts pelvic obliquity may be secondary to spinal deformity may cause leg-length issues acetabular retroversion makes appropriate positioning of acetabular component more difficult intraoperatively Studies Histology loss of superficial chondrocytes replication and breakdown of the tidemark fissuring cartilage destruction with eburnation of subchondral bone Treatment Nonoperative NSAIDs and/or tramadol indications first line treatment for all patients with symptomatic arthritis technique NSAID selection should be based on physician preference, patient acceptability and cost walking stick decreases the joint reaction force on the affected hip when used in the contralateral upper extremity weight loss, activity modification and exercise program/physical therapy indications first line treatment for all patients with symptomatic arthritis BMI > 25 technique exercise aimed at increasing flexibility and aerobic capacity corticosteroid joint injections indications can be therapeutic and/or diagnostic of symptomatic hip osteoarthritis controversial treatments acupuncture viscoelastic joint injections glucosamine and chondroitin Operative arthroscopic debridement indications controversial degenerative labral tears periacetabular osteotomy +/- femoral osteotomy indications symptomatic dysplasia in an adolescent or young adult with concentrically reduced hip and mild-to-moderate arthritis outcomes mixed results literature suggest this can delay need for arthroplasty femoral head resection indications pathological hip lesions painful head subluxation hip resurfacing indications young active, male, patients with hip osteoarthritis total hip arthroplasty (THA) indications end-stage, symptomatic or severe osteoarthritis arthritis preferred treatment for older patients (>50) and those with advanced structural changes
THA - Posterior Approach Technique guide are not considered high yield topics for orthopaedic standardized exams including the ABOS, EBOT and RC. Authors: Derek Bernstein Stephen Incavo THR Direct Anterior Technique guide are not considered high yield topics for orthopaedic standardized exams including the ABOS, EBOT and RC. Authors: Orthobullets Team
QUESTIONS 1 of 2 1 2 Previous Next (OBQ04.70) Which of the following characteristics of stromelysin is incorrect? Review Topic QID: 1175 1 Belongs to the family of proteolytic enzymes called metalloproteinases 14% (113/805) 2 Secreted by chondrocytes 17% (139/805) 3 Inhibited by Tissue Inhibitor of Metalloproteinase 9% (69/805) 4 Inhibited by plasmin 46% (370/805) 5 Degrades cartilage and is thought to play a role in degenerative joint disease 13% (108/805) Select Answer to see Preferred Response PREFERRED RESPONSE 4 (OBQ05.39) Which of the following is a characteristic change in cartilage involved in moderate osteoarthritis? Review Topic QID: 76 1 Decreased thickness of subchondral bone 3% (62/2064) 2 Decreased chondrocyte activity 21% (441/2064) 3 Increased proteoglycan quantity 7% (144/2064) 4 Increased water content 65% (1335/2064) 5 Increased collagen quantity 4% (79/2064) Select Answer to see Preferred Response PREFERRED RESPONSE 4
Success with a Posterior THA - Larry Dorr, M.D. (COA 2017, 1.3) Recon - Hip Osteoarthritis - All Success with a Posterior THA - Larry Dorr, M.D. (COA 2017, 1.3) 4/12/2018 549 views Histology of Osteoarthritis Recon - Hip Osteoarthritis - Pathology Rounds Histology of Osteoarthritis 3/13/2014 2364 views
Hip Osteoarthritis in 46-year-old 5 years after hip arthroscopy (C2893) Recon - Hip Osteoarthritis HPI - The patient had a right hip arthroscopy 5 years ago that included a femoral head re-contouring, os acetabuli resection, and labral reconstruction. Patient has had persistent pain and stiffness ever since that limits his ability to walk distances. How would you treat this patient? 12/11/2017 3842 36 5 Hip dislocation in a paraplegic 40F (C2736) Recon - Hip Osteoarthritis HPI - Traumatic paraplegia at T4 level (ASIA A) 12 years ago with progressive spasticity and difficulty with hygiene since the injury. How would you treat this patient? 11/29/2016 73 1 1 FAILED DISTAL FEMORAL VARUS OSTEOTOMY (C2384) Recon - Hip Osteoarthritis HPI - Valgus deformity of right knee, corrected with distal femoral varus osteotomy. Postoperative x-rays showed good correction with intact medial hidge. 50 days later, during physical therapy, patient felt acute pain and x-rays revealed fractured medial hidge and loss of correction How would you treat the patient at this time (Postoperative P1 images below)? 9/29/2015 65 1 8 See More See Less