We red with a great interest the review of Depypere et al. on pathogenesis and management of fracture-related infection (FRI) [1], Enterobacteriaceae are described as the third microorganisms involved in FRI and the prevention section of the paper report the protective effect of early antibiotic prophylaxis administration. The second international consensus meeting on musculoskeletal infections mentioned that additional coverage for gram-negative organisms should be considered for patients with high-energy open fractures but does not recommend any specific drug [2].