Chordoma is a rare low-grade primary malignant skeletal tumor, which is presumed to derive from notochord remnants. The pathogenesis of chordoma has not been fully elucidated. However, recent advances in the molecular biology studies have identified brachyury underlying the initiation and progression of chordoma cells. More efforts have been made on accumulating evidence of the notochordal origin of chordoma, discovering signaling pathways and identifying crucial targets in chordomagenesis. In this review, we summarize the most recent research findings and focus on the pathophysiology and molecular mechanisms of chordoma.





Polls results
1

On a scale of 1 to 10, rate how much this article will change your clinical practice?

NO change
BIG change
50% Article relates to my practice (1/2)
50% Article does not relate to my practice (1/2)
0% Undecided (0/2)
2

Will this article lead to more cost-effective healthcare?

0% Yes (0/2)
50% No (1/2)
50% Undecided (1/2)
3

Was this article biased? (commercial or personal)

0% Yes (0/2)
100% No (2/2)
0% Undecided (0/2)
4

What level of evidence do you think this article is?

50% Level 1 (1/2)
0% Level 2 (0/2)
50% Level 3 (1/2)
0% Level 4 (0/2)
0% Level 5 (0/2)