Tenosynovial giant cell tumour/pigmented villonodular synovitis (TGCT/PVNS) is a benign neoplasm of synovium and tendon sheath. We conducted a retrospective pooled analysis in three major referral centers.

Patients treated between 1998 and 2008 were examined. Only patients presenting with primary disease or first relapse were included. 5-year local failure free survival (5-year-LFFS) was analysed.

294 patients were included: 254 with new diagnosis and 40 in 1st local recurrence (171 F/123 M; median age: 36 years; tumour size ⩽2 cm in 27% of patients, >2 to ⩽5 cm in 41%, and >5 cm in 32%). A diffuse pattern was reported in 69%, localised in 31%. No metastases were documented. Local failure (LF) was reported in 28% of patients: 36% in diffuse pattern, 14% in localised (p = 0.002); median time to LF: 16 months. With a median follow-up of 4.4 years, 5-year-LFFS was 66%, with multiple (up to five) local recurrences in 40% of relapsed patients. Size < 2 cm, macroscopically complete resection, female gender and new diagnosis were associated with a better local control. After multivariate analysis, a previous relapse was independently associated with local failure.

This study underlines the propensity of TGCT/PVNS to multiple local recurrences. In absence of clinical factors, biological studies are needed to identify prognostic factors of local failure. After a first local recurrence, surgery does not seem to have a curative potential. In these high risk patients, studies addressing the role of target therapies are needed.

Polls results

On a scale of 1 to 10, rate how much this article will change your clinical practice?

NO change
BIG change
75% Article relates to my practice (3/4)
25% Article does not relate to my practice (1/4)
0% Undecided (0/4)

Will this article lead to more cost-effective healthcare?

50% Yes (2/4)
25% No (1/4)
25% Undecided (1/4)

Was this article biased? (commercial or personal)

0% Yes (0/4)
100% No (4/4)
0% Undecided (0/4)

What level of evidence do you think this article is?

0% Level 1 (0/4)
50% Level 2 (2/4)
50% Level 3 (2/4)
0% Level 4 (0/4)
0% Level 5 (0/4)