There is great interest in new treatments of osteoporosis owing to general ageing of population and increased risk for fragility fractures in the elderly. Current therapies show a good efficacy in improving bone quality and bone density, but, in spite of a certain reduction in fracture rate, according to each treatment, the problem of osteoporotic fractures is yet far from to be solved. Moreover, some treatments may produce different side effects. Denosumab (Dmab), a receptor activator of nuclear factor kappa-B ligand (RANKL)-inhibitor, is an agent recently introduced in clinical practice for treatment of osteoporosis of postmenopausal women. Dmab has improved bone mineral density and prevented new vertebral and non-vertebral fractures with a similar efficacy in comparison with alendronate. Many clinical studies showed Dmab produces also significant improvement versus placebo in bone quality as indicated by decreasing markers of bone turnover. Patients using Dmab reported less risk of AFF (Atypical Femoral Fractures) and ONJ (Osteonecrosis of the Jaw) with an increased number of cellulitis. Here, we review articles using Dmab for female post-menopausal osteoporosis.





Polls results
1

On a scale of 1 to 10, rate how much this article will change your clinical practice?

NO change
BIG change
100% Article relates to my practice (1/1)
0% Article does not relate to my practice (0/1)
0% Undecided (0/1)
2

Will this article lead to more cost-effective healthcare?

100% Yes (1/1)
0% No (0/1)
0% Undecided (0/1)
3

Was this article biased? (commercial or personal)

0% Yes (0/1)
100% No (1/1)
0% Undecided (0/1)
4

What level of evidence do you think this article is?

0% Level 1 (0/1)
0% Level 2 (0/1)
100% Level 3 (1/1)
0% Level 4 (0/1)
0% Level 5 (0/1)