Acute subclavian artery thrombosis is a rare cause of upper extremity or cerebral ischemia. Diagnosis and origin must be rapidly established, to allow an appropriate management in order to prevent catastrophic vertebro-basilar stroke. Surgery is often complex and inappropriate in emergency. Angioplasty and stenting are widespread used, in the management of subclavian artery stenosis [1–3]. Stenting an acute subclavian artery thrombosis is technically feasible, in intention to trap thrombus underlies. However, protection to vertebro-basilar embolism or treatment is a remaining successful key-point of endovascular management. Herein, we report two cases of acute subclavian thrombosis treated by percutaneous endovascular stenting of a culprit lesion, while technique to treat (1st case) or to prevent vertebra-basilar embolism (2nd case) were deployed.