Rhabdomyosarcoma is a soft tissue sarcoma arising from cells of a mesenchymal or skeletal muscle lineage. Alveolar rhabdomyosarcoma (ARMS) is more aggressive than the more common embryonal (ERMS) subtype. ARMS is more prone to metastasis and carries a poorer prognosis. In contrast to ERMS, the majority of ARMS tumors carry one of several characteristic chromosomal translocations, such as t(2;13)(q35;q14), which results in the expression of a PAX3-FOXO1 fusion transcription factor. In this review we discuss the genes that cooperate with PAX3-FOXO1, as well as the target genes of the fusion transcription factor that contribute to various aspects of ARMS tumorigenesis. The characterization of these pathways will lead to a better understanding of ARMS tumorigenesis and will allow the design of novel targeted therapies that will lead to better treatment for this aggressive pediatric tumor.





Polls results
1

On a scale of 1 to 10, rate how much this article will change your clinical practice?

NO change
BIG change
100% Article relates to my practice (1/1)
0% Article does not relate to my practice (0/1)
0% Undecided (0/1)
2

Will this article lead to more cost-effective healthcare?

0% Yes (0/1)
100% No (1/1)
0% Undecided (0/1)
3

Was this article biased? (commercial or personal)

0% Yes (0/1)
100% No (1/1)
0% Undecided (0/1)
4

What level of evidence do you think this article is?

0% Level 1 (0/1)
0% Level 2 (0/1)
100% Level 3 (1/1)
0% Level 4 (0/1)
0% Level 5 (0/1)